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Literature DB >> 22434084

Understanding the sexome: measuring and reporting sex differences in gene systems.

Abstract

The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome," which is the sum of sex-biased effects on gene networks and cell systems. The global search for sites and mechanisms of sex-specific regulation in diverse tissues will provide unanticipated insights into physiological regulation and targets for novel therapies.

Mesh：

Year: 2012 PMID： 22434084 PMCID： PMC3359607 DOI： 10.1210/en.2011-2134

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736

43 in total

1. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig.

Authors: C H PHOENIX; R W GOY; A A GERALL; W C YOUNG
Journal: Endocrinology Date: 1959-09 Impact factor: 4.736

2. Effects of gender on gene expression in the blood of ischemic stroke patients.

Authors: Yingfang Tian; Boryana Stamova; Glen C Jickling; Dazhi Liu; Bradley P Ander; Cheryl Bushnell; Xinhua Zhan; Ryan R Davis; Piero Verro; William C Pevec; Nasim Hedayati; David L Dawson; Jane Khoury; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp
Journal: J Cereb Blood Flow Metab Date: 2011-12-14 Impact factor: 6.200

3. Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats.

Authors: Miklós Sárvári; Imre Kalló; Erik Hrabovszky; Norbert Solymosi; Kinga Tóth; István Likó; Béla Molnár; Károly Tihanyi; Zsolt Liposits
Journal: Endocrinology Date: 2010-06-09 Impact factor: 4.736

4. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.

Authors: Atila van Nas; Debraj Guhathakurta; Susanna S Wang; Nadir Yehya; Steve Horvath; Bin Zhang; Leslie Ingram-Drake; Gautam Chaudhuri; Eric E Schadt; Thomas A Drake; Arthur P Arnold; Aldons J Lusis
Journal: Endocrinology Date: 2008-10-30 Impact factor: 4.736

Review 8. Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game.

Authors: Arthur P Arnold
Journal: Exp Neurol Date: 2014-02-07 Impact factor: 5.330

9. Sexual Inequality in the Cancer Cell.

Authors: Arthur P Arnold; Christine M Disteche
Journal: Cancer Res Date: 2018-10-01 Impact factor: 12.701

Review 10. Systems genetics approaches to understand complex traits.

Authors: Mete Civelek; Aldons J Lusis
Journal: Nat Rev Genet Date: 2013-12-03 Impact factor: 53.242

Understanding the sexome: measuring and reporting sex differences in gene systems.

1. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig.

2. Effects of gender on gene expression in the blood of ischemic stroke patients.

3. Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats.

4. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.

5. Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain.

6. Tissue-specific expression and regulation of sexually dimorphic genes in mice.

7. Sex differences in autoimmune diseases.

8. Gender dimorphism in the exercise-naïve murine skeletal muscle proteome.

Review 9. Sexually dimorphic gene expression in the heart of mice and men.

10. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity.

Review 1. Immune cells have sex and so should journal articles.

Review 2. Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain.

Review 3. Imprinted and X-linked non-coding RNAs as potential regulators of human placental function.

4. Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.

Review 5. A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism.

Review 6. Sex differences in metabolism and cardiometabolic disorders.

7. Embedding concepts of sex and gender health differences into medical curricula.

Review 8. Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game.

9. Sexual Inequality in the Cancer Cell.

Review 10. Systems genetics approaches to understand complex traits.