BACKGROUND: Preterm infants with progressive post-hemorrhagic ventricular dilatation (PHVD) in the absence of associated parenchymal lesions may have a normal neurodevelopmental outcome. OBJECTIVES: To evaluate neurodevelopmental and cognitive outcomes among preterm infants with severe intraventricular hemorrhage (IVH) and PHVD requiring neurosurgical intervention. METHODS: 32 preterm infants were admitted to a neonatal intensive care unit with PHVD requiring neurosurgical intervention, and were seen in the follow-up clinic for standardized cognitive, behavioral and neurological assessments between 5 and 8 years of age. Only preterm infants with a gestational age (GA) of <30 weeks, as well as preterm and full-term infants with PHVD and full-term infants with perinatal asphyxia are seen in our follow-up clinic at this age. There were 23 infants with a GA of <30 weeks in this study population. For these 23, matched controls were available and compared with the IVH group. RESULTS: The majority (59.4%) had no impairments. None of the children with grade III and 8 of the 15 children (53%) with grade IV hemorrhage developed cerebral palsy. More subtle motor problems assessed with the Movement-ABC score were seen in 39% (n = 9); the mean IQ of all children was 93.4, and 29% of the children had an IQ of <85 (-1 SD). Timing of intervention did not have a beneficial effect on outcome. With respect to cognition, no significant differences were found between the IVH and the control group. CONCLUSION: The majority of the children in our population had no impairments. Cerebral palsy was not seen in any of the infants with a grade III hemorrhage.
BACKGROUND: Preterm infants with progressive post-hemorrhagic ventricular dilatation (PHVD) in the absence of associated parenchymal lesions may have a normal neurodevelopmental outcome. OBJECTIVES: To evaluate neurodevelopmental and cognitive outcomes among preterm infants with severe intraventricular hemorrhage (IVH) and PHVD requiring neurosurgical intervention. METHODS: 32 preterm infants were admitted to a neonatal intensive care unit with PHVD requiring neurosurgical intervention, and were seen in the follow-up clinic for standardized cognitive, behavioral and neurological assessments between 5 and 8 years of age. Only preterm infants with a gestational age (GA) of <30 weeks, as well as preterm and full-term infants with PHVD and full-term infants with perinatal asphyxia are seen in our follow-up clinic at this age. There were 23 infants with a GA of <30 weeks in this study population. For these 23, matched controls were available and compared with the IVH group. RESULTS: The majority (59.4%) had no impairments. None of the children with grade III and 8 of the 15 children (53%) with grade IV hemorrhage developed cerebral palsy. More subtle motor problems assessed with the Movement-ABC score were seen in 39% (n = 9); the mean IQ of all children was 93.4, and 29% of the children had an IQ of <85 (-1 SD). Timing of intervention did not have a beneficial effect on outcome. With respect to cognition, no significant differences were found between the IVH and the control group. CONCLUSION: The majority of the children in our population had no impairments. Cerebral palsy was not seen in any of the infants with a grade III hemorrhage.
Authors: Maria Luisa Tataranno; Nathalie H P Claessens; Pim Moeskops; Mona C Toet; Karina J Kersbergen; Giuseppe Buonocore; Ivana Išgum; Alexander Leemans; Serena Counsell; Floris Groenendaal; Linda S de Vries; Manon J N L Benders Journal: Pediatr Res Date: 2018-01-17 Impact factor: 3.756
Authors: Margaretha J Brouwer; Karina J Kersbergen; Britt J M van Kooij; Manon J N L Benders; Ingrid C van Haastert; Corine Koopman-Esseboom; Jeffrey J Neil; Linda S de Vries; Hiroyuki Kidokoro; Terrie E Inder; Floris Groenendaal Journal: PLoS One Date: 2017-05-09 Impact factor: 3.240
Authors: R MacLeod; J N Paulson; N Okalany; F Okello; L Acom; J Ikiror; F M Cowan; C J Tann; L E Dyet; C F Hagmann; K Burgoine Journal: BMC Pediatr Date: 2021-01-06 Impact factor: 2.125