K Diwakar1, Walter J Hader2,3,4,5, A Soraisham1,2,3,5, Harish Amin1,3,5, Selphee Tang5, Kelly Bullivant3,5, Majeeda Kamaluddeen1,3,5, Abhay Lodha6,7,8,9,10,11. 1. Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada. 2. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. 3. Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada. 4. Section of Pediatric Neurosurgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada. 5. Alberta Health Services, Calgary, Alberta, Canada. 6. Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca. 7. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca. 8. Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca. 9. Alberta Health Services, Calgary, Alberta, Canada. aklodha@ucalgary.ca. 10. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca. 11. Department of Pediatrics, Cumming School of Medicine, Foothills Medical Centre, C211-1403 29 St NW, Calgary, AB,, T2N2T9, Canada. aklodha@ucalgary.ca.
Abstract
OBJECTIVE: To compare long-term neurodevelopmental and growth (NDG) outcomes at 3 y corrected gestational age (GA) in premature infants with grade ≥ III intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus who were treated with ventriculo-peritoneal shunt with those who were not treated with shunt. METHODS: In a retrospective cohort study, NDG outcomes were compared between preterm infants of <29 wk GA with IVH treated with shunt (IVHS) and IVH with no shunt (IVHNS). This was a single centre study. The primary outcome was moderate to severe cerebral palsy (CP). RESULTS: Of 1762 preterm infants who survived to discharge, 90 had grade ≥ III IVH. Infants in IVHS group had more grade IV IVH than IVHNS (p < 0.05). Seventy percent of the patients in IVHNS groups had no hydrocephalus. IVHS group had increased CP (76% vs. 30%; p 0.003), and higher odds of CP after controlling for GA and IVH grade [odds ratio (OR); 4.23 (1.38 to 13.00)]. Growth delay was not different between groups. CONCLUSIONS: Infants with IVHS are at increased risk of CP but not growth delay.
OBJECTIVE: To compare long-term neurodevelopmental and growth (NDG) outcomes at 3 y corrected gestational age (GA) in premature infants with grade ≥ III intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus who were treated with ventriculo-peritoneal shunt with those who were not treated with shunt. METHODS: In a retrospective cohort study, NDG outcomes were compared between preterm infants of <29 wk GA with IVH treated with shunt (IVHS) and IVH with no shunt (IVHNS). This was a single centre study. The primary outcome was moderate to severe cerebral palsy (CP). RESULTS: Of 1762 preterm infants who survived to discharge, 90 had grade ≥ III IVH. Infants in IVHS group had more grade IV IVH than IVHNS (p < 0.05). Seventy percent of the patients in IVHNS groups had no hydrocephalus. IVHS group had increased CP (76% vs. 30%; p 0.003), and higher odds of CP after controlling for GA and IVH grade [odds ratio (OR); 4.23 (1.38 to 13.00)]. Growth delay was not different between groups. CONCLUSIONS:Infants with IVHS are at increased risk of CP but not growth delay.
Authors: R J Kuczmarski; C L Ogden; L M Grummer-Strawn; K M Flegal; S S Guo; R Wei; Z Mei; L R Curtin; A F Roche; C L Johnson Journal: Adv Data Date: 2000-06-08