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Literature DB >> 22074928

Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches.

Abstract

Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.

Entities: Disease

Mesh：

Substances：
Opsins
Retinaldehyde

Year: 2011 PMID： 22074928 PMCID： PMC3265844 DOI： 10.1074/jbc.R111.303008

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

95 in total

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Authors: G L Fain; H R Matthews; M C Cornwall; Y Koutalos
Journal: Physiol Rev Date: 2001-01 Impact factor: 37.312

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Authors: V J Kefalov; R K Crouch; M C Cornwall
Journal: Neuron Date: 2001-03 Impact factor: 17.173

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Authors: J Ma; S Znoiko; K L Othersen; J C Ryan; J Das; T Isayama; M Kono; D D Oprian; D W Corson; M C Cornwall; D A Cameron; F I Harosi; C L Makino; R K Crouch
Journal: Neuron Date: 2001-11-08 Impact factor: 17.173

Review 4. Activation, deactivation, and adaptation in vertebrate photoreceptor cells.

Authors: M E Burns; D A Baylor
Journal: Annu Rev Neurosci Date: 2001 Impact factor: 12.449

Review 5. G proteins and phototransduction.

Authors: Vadim Y Arshavsky; Trevor D Lamb; Edward N Pugh
Journal: Annu Rev Physiol Date: 2002 Impact factor: 19.318

Review 6. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina.

Authors: J K McBee; K Palczewski; W Baehr; D R Pepperberg
Journal: Prog Retin Eye Res Date: 2001-07 Impact factor: 21.198

7. Molecular mechanism of spontaneous pigment activation in retinal cones.

Authors: Alapakkam P Sampath; Denis A Baylor
Journal: Biophys J Date: 2002-07 Impact factor: 4.033

Review 8. How vision begins: an odyssey.

Authors: Dong-Gen Luo; Tian Xue; King-Wai Yau
Journal: Proc Natl Acad Sci U S A Date: 2008-07-16 Impact factor: 11.205

9. Low amplification and fast visual pigment phosphorylation as mechanisms characterizing cone photoresponses.

Authors: S Tachibanaki; S Tsushima; S Kawamura
Journal: Proc Natl Acad Sci U S A Date: 2001-11-13 Impact factor: 11.205

10. Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina.

Authors: Valerie C Fleisch; Helia B Schonthaler; Johannes von Lintig; Stephan C F Neuhauss
Journal: J Neurosci Date: 2008-08-13 Impact factor: 6.167

35 in total

Review 1. Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Authors: Oliver P Ernst; David T Lodowski; Marcus Elstner; Peter Hegemann; Leonid S Brown; Hideki Kandori
Journal: Chem Rev Date: 2013-12-23 Impact factor: 60.622

Review 2. Retinoic acid signaling pathways in development and diseases.

Authors: Bhaskar C Das; Pritam Thapa; Radha Karki; Sasmita Das; Sweta Mahapatra; Ting-Chun Liu; Ingrid Torregroza; Darren P Wallace; Suman Kambhampati; Peter Van Veldhuizen; Amit Verma; Swapan K Ray; Todd Evans
Journal: Bioorg Med Chem Date: 2013-11-22 Impact factor: 3.641

Review 3. Chemistry of the retinoid (visual) cycle.

Authors: Philip D Kiser; Marcin Golczak; Krzysztof Palczewski
Journal: Chem Rev Date: 2013-07-11 Impact factor: 60.622

4. Tackling Primary Cilia Dysfunction in Photoreceptor Degenerative Diseases of the Eye.

Authors: Sarah Servattalab; Ozge Yildiz; Hemant Khanna
Journal: Int J Ophthalmic Pathol Date: 2012-06-24

5. The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation.

Authors: Xin Wang; David C Plachetzki; Rick H Cote
Journal: J Biol Chem Date: 2019-04-08 Impact factor: 5.157

6. Optogenetic Modulation of Ion Channels by Photoreceptive Proteins.

Authors: Hisao Tsukamoto; Yuji Furutani
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

7. Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.

Authors: Christopher T Schafer; Jonathan F Fay; Jay M Janz; David L Farrens
Journal: Proc Natl Acad Sci U S A Date: 2016-10-04 Impact factor: 11.205