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Literature DB >> 22072752

Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo.

Qinfang Liu¹, Chuanling Qiao, Henju Marjuki, Bhupinder Bawa, Jingqun Ma, Stephane Guillossou, Richard J Webby, Jürgen A Richt, Wenjun Ma.

Abstract

Triple reassortant swine influenza viruses (SIVs) and 2009 pandemic H1N1 (pH1N1) virus contain an avian-origin PB2 with 271A, 590S, 591R, and 627E. To evaluate the role of PB2 271A, 590S, and 591R in the replication and virulence of SIV, single (1930-TX98-PB2-271T)-, double (1930-TX98-PB2-590A591A)-, and triple (1930-TX98-PB2-271T590A591A)-mutated viruses were generated in the background of the H1N1 A/swine/Iowa/15/30 (1930) virus with an avian-origin PB2 from the triple-reassortant A/swine/Texas/4199-2/98 (TX98) virus, called the parental 1930-TX98-PB2. Compared to parental virus and single- and double-mutated viruses, the triple-mutated virus replicated less efficiently in cell cultures and was attenuated in mice. These results suggest that a combination of 271A with the 590/591 SR polymorphism is critical for pH1N1 and triple-reassortant SIVs for efficient replication and adaptation in mammals.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 22072752 PMCID： PMC3255826 DOI： 10.1128/JVI.05699-11

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

21 in total

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10. Serologic evidence of pandemic (H1N1) 2009 infection in dogs, Italy.

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34 in total

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Authors: Brittany L DesRochers; Rita E Chen; Anshu P Gounder; Amelia K Pinto; Traci Bricker; Camille N Linton; Corianne D Rogers; Graham D Williams; Richard J Webby; Adrianus C M Boon
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4. Pathogenesis and Transmission of Genetically Diverse Swine-Origin H3N2 Variant Influenza A Viruses from Multiple Lineages Isolated in the United States, 2011-2016.

Authors: Xiangjie Sun; Joanna A Pulit-Penaloza; Jessica A Belser; Claudia Pappas; Melissa B Pearce; Nicole Brock; Hui Zeng; Hannah M Creager; Natosha Zanders; Yunho Jang; Terrence M Tumpey; C Todd Davis; Taronna R Maines
Journal: J Virol Date: 2018-07-31 Impact factor: 5.103

Review 5. Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.

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6. Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position.

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