OBJECTIVE: To explore the relationship between stomach cancer (SC), by histological type, and occupations and occupational exposures. METHODS: The authors conducted a hospital-based case-control study in south-east Spain. Subjects were 399 incident histological confirmed SC cases (241 intestinal and 109 diffuse adenocarcinomas) and 455 controls frequency matched by sex, age and province of residence. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the FINJEM Job Exposure Matrix. ORs were estimated by unconditional logistic regression adjusting for matching variables and education, smoking, alcohol and diet. RESULTS: In men, statistically significant increased risk of the diffuse subtype was found for 'cooks' (OR 8.02), 'wood-processing-plant operators' (OR 8.13) and 'food and related products machine operators' (OR 5.40); for the intestinal subtype, a borderline association was found for 'miners and quarry workers' (OR men 4.22, 95% CI 0.80 to 22.14). Significant increased risk was observed between the diffuse subtype of SC and the highest level of exposure to 'pesticides' (OR(H) both sexes 10.39, 95% CI 2.51 to 43.02, p(trend)=0.02) and between the intestinal subtype and asbestos (OR(H) men 3.71, 95% CI 1.40 to 9.83, p(trend)=0.07). Restricted analyses of exposures of 15 years and longer showed significant associations between the diffuse subtype and the exposure to 'wood dust' (OR men 3.05). CONCLUSIONS: This study supports the relationship previously suggested between SC and occupational exposure to dusty and high temperature environments. Several occupations may also increase the risk of diffuse SC but not the intestinal subtype.
OBJECTIVE: To explore the relationship between stomach cancer (SC), by histological type, and occupations and occupational exposures. METHODS: The authors conducted a hospital-based case-control study in south-east Spain. Subjects were 399 incident histological confirmed SC cases (241 intestinal and 109 diffuse adenocarcinomas) and 455 controls frequency matched by sex, age and province of residence. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the FINJEM Job Exposure Matrix. ORs were estimated by unconditional logistic regression adjusting for matching variables and education, smoking, alcohol and diet. RESULTS: In men, statistically significant increased risk of the diffuse subtype was found for 'cooks' (OR 8.02), 'wood-processing-plant operators' (OR 8.13) and 'food and related products machine operators' (OR 5.40); for the intestinal subtype, a borderline association was found for 'miners and quarry workers' (OR men 4.22, 95% CI 0.80 to 22.14). Significant increased risk was observed between the diffuse subtype of SC and the highest level of exposure to 'pesticides' (OR(H) both sexes 10.39, 95% CI 2.51 to 43.02, p(trend)=0.02) and between the intestinal subtype and asbestos (OR(H) men 3.71, 95% CI 1.40 to 9.83, p(trend)=0.07). Restricted analyses of exposures of 15 years and longer showed significant associations between the diffuse subtype and the exposure to 'wood dust' (OR men 3.05). CONCLUSIONS: This study supports the relationship previously suggested between SC and occupational exposure to dusty and high temperature environments. Several occupations may also increase the risk of diffuse SC but not the intestinal subtype.
Authors: Georgia Martimianaki; Paola Bertuccio; Gianfranco Alicandro; Claudio Pelucchi; Francesca Bravi; Greta Carioli; Rossella Bonzi; Charles S Rabkin; Linda M Liao; Rashmi Sinha; Ken Johnson; Jinfu Hu; Domenico Palli; Monica Ferraroni; Nuno Lunet; Samantha Morais; Shoichiro Tsugane; Akihisa Hidaka; Gerson Shigueaki Hamada; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; David Zaridze; Dmitry Maximovitch; Nuria Aragonés; Vicente Martin; Mary H Ward; Jesus Vioque; Manoli Garcia de la Hera; Zuo-Feng Zhang; Robert C Kurtz; Pagona Lagiou; Areti Lagiou; Antonia Trichopoulou; Anna Karakatsani; Reza Malekzadeh; M Constanza Camargo; Maria Paula Curado; Stefania Boccia; Paolo Boffetta; Eva Negri; Carlo La Vecchia Journal: Eur J Cancer Prev Date: 2022-03-01 Impact factor: 2.164
Authors: Gianfranco Alicandro; Paola Bertuccio; Giulia Collatuzzo; Claudio Pelucchi; Rossella Bonzi; Linda M Liao; Charles S Rabkin; Rashmi Sinha; Eva Negri; Michela Dalmartello; David Zaridze; Dmitry Maximovich; Jesus Vioque; Manoli Garcia de la Hera; Shoichiro Tsugane; Akihisa Hidaka; Gerson Shigueaki Hamada; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; Reza Malekzadeh; Farhad Pourfarzi; Zuo-Feng Zhang; Robert C Kurtz; M Constanza Camargo; Maria Paula Curado; Nuno Lunet; Paolo Boffetta; Carlo La Vecchia Journal: Br J Cancer Date: 2022-05-27 Impact factor: 9.075
Authors: Georgia Martimianaki; Gianfranco Alicandro; Claudio Pelucchi; Rossella Bonzi; Matteo Rota; Jinfu Hu; Kenneth C Johnson; Charles S Rabkin; Linda M Liao; Rashmi Sinha; Zuo-Feng Zhang; Michela Dalmartello; Nuno Lunet; Samantha Morais; Domenico Palli; Monica Ferraroni; Guo-Pei Yu; Shoichiro Tsugane; Akihisa Hidaka; Maria Paula Curado; Emmanuel Dias-Neto; David Zaridze; Dmitry Maximovitch; Jesus Vioque; Manoli Garcia de la Hera; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; Gerson Shigueaki Hamada; Mary H Ward; Lina Mu; Reza Malekzadeh; Farhad Pourfarzi; Antonia Trichopoulou; Anna Karakatsani; Robert C Kurtz; Areti Lagiou; Pagona Lagiou; Stefania Boccia; Paolo Boffetta; M Constanza Camargo; Eva Negri; Carlo La Vecchia Journal: Br J Cancer Date: 2022-05-24 Impact factor: 9.075
Authors: Giulia Collatuzzo; Federica Teglia; Claudio Pelucchi; Eva Negri; Charles S Rabkin; Linda M Liao; Rashmi Sinha; Lizbeth López-Carrillo; Nuno Lunet; Samantha Morais; Nuria Aragonés; Victor Moreno; Jesus Vioque; Manoli Garcia de la Hera; Mary H Ward; Reza Malekzadeh; Mohammadreza Pakseresht; Raúl Ulises Hernández-Ramírez; Malaquias López-Cervantes; Rossella Bonzi; Michela Dalmartello; Shoichiro Tsugane; Akihisa Hidaka; M Constanza Camargo; Maria Paula Curado; Zuo-Feng Zhang; Nadia Zubair; Carlo La Vecchia; Shailja Shah; Paolo Boffetta Journal: Nutrients Date: 2022-06-20 Impact factor: 6.706