Michela Dalmartello1, Federica Turati2,3, Zuo-Feng Zhang4, Nuno Lunet5,6,7, Matteo Rota8, Rossella Bonzi1, Carlotta Galeone9, Georgia Martimianaki1,10, Domenico Palli11, Monica Ferraroni1, Guo-Pei Yu12, Samantha Morais5,6,7, Reza Malekzadeh13, Lizbeth López-Carrillo14, David Zaridze15, Dmitry Maximovitch15, Nuria Aragonés16,17, Guillermo Fernández-Tardón18, Vicente Martin16,19, Jesus Vioque16,20, Manoli Garcia de la Hera16,20, Maria Paula Curado21, Felipe Jose Fernandez Coimbra22, Paulo Assumpcao23, Mohammadreza Pakseresht13,24,25, Jinfu Hu26, Raúl Ulises Hernández-Ramírez27, Mary H Ward28, Farhad Pourfarzi13,29, Lina Mu30, Shoichiro Tsugane31,32, Akihisa Hidaka31, Pagona Lagiou33,34, Areti Lagiou35, Antonia Trichopoulou10, Anna Karakatsani10,36, Paolo Boffetta37,38, M Costanza Camargo28, Eva Negri1,38, Carlo La Vecchia1, Claudio Pelucchi1. 1. Branch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 2. Branch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. federica.turati@unimi.it. 3. Unit of Medical Statistics and Biometry, National Cancer Institute of Milan, Milan, Italy. federica.turati@unimi.it. 4. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA. 5. EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal. 6. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. 7. Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal. 8. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. 9. Bicocca Applied Statistics Center (B-ASC), Università degli Studi di Milano-Bicocca, Milan, Italy. 10. Hellenic Health Foundation, Athens, Greece. 11. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy. 12. Medical Informatics Center, Peking University, Peking, China. 13. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 14. Mexico National Institute of Public Health, Morelos, Mexico. 15. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia. 16. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. 17. Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain. 18. Health Research Institute of Asturias, ISPA and IUOPA University of Oviedo, Oviedo, Spain. 19. Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain. 20. Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL-UMH, 46020, Alicante, Spain. 21. Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil. 22. Department of Abdominal Surgery, A.C.Camargo Cancer Center, São Paulo, SP, Brazil. 23. Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil. 24. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada. 25. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom. 26. Harbin Medical University, Harbin, China. 27. Department of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, CT, USA. 28. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. 29. Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran. 30. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA. 31. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan. 32. National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan. 33. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. 34. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 35. Department of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece. 36. 2nd Pulmonary Medicine Department, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Haidari, Greece. 37. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA. 38. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Abstract
BACKGROUND: The role of allium vegetables on gastric cancer (GC) risk remains unclear. METHODS: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. RESULTS: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. CONCLUSIONS: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
BACKGROUND: The role of allium vegetables on gastric cancer (GC) risk remains unclear. METHODS: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. RESULTS: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. CONCLUSIONS: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
Authors: Mitchell H Gail; Ruth M Pfeiffer; Linda M Brown; Lian Zhang; Jun-ling Ma; Kai-feng Pan; Wei-dong Liu; Wei-cheng You Journal: Helicobacter Date: 2007-10 Impact factor: 5.753
Authors: M H Ward; R Sinha; E F Heineman; N Rothman; R Markin; D D Weisenburger; P Correa; S H Zahm Journal: Int J Cancer Date: 1997-03-28 Impact factor: 7.396
Authors: Silvia Deandrea; Roberto Foschi; Carlotta Galeone; Carlo La Vecchia; Eva Negri; Jinfu Hu Journal: Eur J Cancer Prev Date: 2010-01 Impact factor: 2.497