BACKGROUND: Decreased anxiety has been reported among women with false-positive results in mammography screening programs. No long-term effects have been fully demonstrated, and the findings for anxiety and depression are contradictory. Few studies have addressed changes in health-related quality of life (HRQOL). OBJECTIVE: The objective was to study the short- and long-term effects such as changes in anxiety, depression, and HRQOL among women with false-positive results. METHODS: With a longitudinal study design, data were collected on anxiety and depression (Hospital Anxiety and Depression Scale) and HRQOL (Short-Form 36 [SF-36] Health Survey) among women with false-positive results before screening, at recall, and at 3 and 6 months after screening. Controls (negative results in screening) were measured before screening and at 6 months after. RESULTS: Women with false-positive results (n = 128) showed increased anxiety at recall (mean, 4.6 [SD, 3.7]) versus before screening (P = .04), but this decreased until 6 months after screening. Depression was increased until 6 months after screening (not statistically significant). Women with false-positive results scored lower than did control subjects on general health (P = .02) and mental health (P = .03) and higher on depression (P = .045) at 6 months after screening. CONCLUSIONS: Efforts should be made to minimize anxiety at recall and depression after screening. Further research is needed on the long-term effects of recall and any effects on HRQOL. IMPLICATIONS FOR PRACTICE: Information about the prevalence of false-positive results and time until unambiguous diagnostic results should be improved. Information leaflet based on evidence needs to be continually updated.
BACKGROUND: Decreased anxiety has been reported among women with false-positive results in mammography screening programs. No long-term effects have been fully demonstrated, and the findings for anxiety and depression are contradictory. Few studies have addressed changes in health-related quality of life (HRQOL). OBJECTIVE: The objective was to study the short- and long-term effects such as changes in anxiety, depression, and HRQOL among women with false-positive results. METHODS: With a longitudinal study design, data were collected on anxiety and depression (Hospital Anxiety and Depression Scale) and HRQOL (Short-Form 36 [SF-36] Health Survey) among women with false-positive results before screening, at recall, and at 3 and 6 months after screening. Controls (negative results in screening) were measured before screening and at 6 months after. RESULTS:Women with false-positive results (n = 128) showed increased anxiety at recall (mean, 4.6 [SD, 3.7]) versus before screening (P = .04), but this decreased until 6 months after screening. Depression was increased until 6 months after screening (not statistically significant). Women with false-positive results scored lower than did control subjects on general health (P = .02) and mental health (P = .03) and higher on depression (P = .045) at 6 months after screening. CONCLUSIONS: Efforts should be made to minimize anxiety at recall and depression after screening. Further research is needed on the long-term effects of recall and any effects on HRQOL. IMPLICATIONS FOR PRACTICE: Information about the prevalence of false-positive results and time until unambiguous diagnostic results should be improved. Information leaflet based on evidence needs to be continually updated.
Authors: Ilana F Gareen; Fenghai Duan; Erin M Greco; Bradley S Snyder; Phillip M Boiselle; Elyse R Park; Dennis Fryback; Constantine Gatsonis Journal: Cancer Date: 2014-07-25 Impact factor: 6.860
Authors: Janie M Lee; Kathryn P Lowry; Jessica E Cott Chubiz; J Shannon Swan; Tina Motazedi; Elkan F Halpern; Anna N A Tosteson; G Scott Gazelle; Karen Donelan Journal: Breast Date: 2020-02-13 Impact factor: 4.380
Authors: Carsten Oliver Schmidt; Elizabeth Sierocinski; Katrin Hegenscheid; Sebastian E Baumeister; Hans J Grabe; Henry Völzke Journal: Eur J Epidemiol Date: 2015-11-23 Impact factor: 8.082