Literature DB >> 22066797

Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute.

Hongli Zhu1, Kunping Yan, Xiaodong Dang, He Huang, Erfang Chen, Bang Chen, Chao Luo, Thomas Ming Swi Chang, Penggao Dai, Chao Chen.   

Abstract

Polymerized Porcine Hemoglobin (pPolyHb), a hemoglobin-based oxygen carrier (HBOC), was developed as a potential red blood substitute for clinical applications. Assessment of its effects on the immune system is an important component of the overall safety evaluation of HBOC. For this purpose, we assessed three inflammation indicators, including complement C3a, IL-6, and TNF-? in cultured cells and in a rat model when pPolyHb was incubated or administrated with the cells/animals. Our results suggested that the levels of these three indicators were not statistically changed upon pPolyHb stimulation, indicating that pPolyHb is not immunotoxic to cells and animals in this aspect.

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Year:  2011        PMID： 22066797      PMCID： PMC3584014          DOI： 10.3109/10731199.2011.631499

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  22 in total

Review 1.  Progress in the development of RBC substitutes.

Authors:  C P Stowell; J Levin; B D Spiess; R M Winslow
Journal:  Transfusion       Date:  2001-02       Impact factor: 3.157

2.  The immunologic response to injury.

Authors:  J A Mannick; M L Rodrick; J A Lederer
Journal:  J Am Coll Surg       Date:  2001-09       Impact factor: 6.113

3.  The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro.

Authors:  Delio P Ortegon; Patricia S Dixon; Kathryn K Crow; Deborah L Mueller; Jeffrey D Kerby
Journal:  J Trauma       Date:  2003-10

Review 4.  Current concepts of the inflammatory response after major trauma: an update.

Authors:  P V Giannoudis
Journal:  Injury       Date:  2003-06       Impact factor: 2.586

5.  Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction.

Authors:  W L Biffl; E E Moore; P J Offner; D J Ciesla; R J Gonzalez; C C Silliman
Journal:  J Trauma       Date:  2001-03

Review 6.  alphaalpha-crosslinked hemoglobin: was failure predicted by preclinical testing?

Authors:  R M Winslow
Journal:  Vox Sang       Date:  2000       Impact factor: 2.144

7.  Human neutrophil activation and increased adhesion by various resuscitation fluids.

Authors:  P Rhee; D Wang; P Ruff; B Austin; S DeBraux; K Wolcott; D Burris; G Ling; L Sun
Journal:  Crit Care Med       Date:  2000-01       Impact factor: 7.598

8.  Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion.

Authors:  Hongli Zhu; Xiaodong Dang; Kunping Yan; Penggao Dai; Chao Luo; Jun Ma; Yan Li; Thomas Ming Swi Chang; Chao Chen
Journal:  Artif Cells Blood Substit Immobil Biotechnol       Date:  2011-03-07

9.  Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.

Authors:  Jeffrey L Johnson; Ernest E Moore; Ricardo J Gonzalez; Nikki Fedel; David A Partrick; Christopher C Silliman
Journal:  J Trauma       Date:  2003-01

10.  Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin.

Authors:  J R Hess; V W MacDonald; W W Brinkley
Journal:  J Appl Physiol (1985)       Date:  1993-04
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  2 in total

1.  Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.

Authors:  Paul W Buehler; Jin Hyen Baek; Christina Lisk; Ian Connor; Tim Sullivan; Douglas Kominsky; Susan Majka; Kurt R Stenmark; Eva Nozik-Grayck; Joe Bonaventura; David C Irwin
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2012-06-22       Impact factor: 5.464

2.  Direct comparison of oligochaete erythrocruorins as potential blood substitutes.

Authors:  Devon Zimmerman; Matthew DiIusto; Jack Dienes; Osheiza Abdulmalik; Jacob J Elmer
Journal:  Bioeng Transl Med       Date:  2017-07-19
  2 in total

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