Literature DB >> 21381891

Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion.

Hongli Zhu1, Xiaodong Dang, Kunping Yan, Penggao Dai, Chao Luo, Jun Ma, Yan Li, Thomas Ming Swi Chang, Chao Chen.   

Abstract

The objective of the present study is to evaluate the pharmacodynamic properties of polymerized porcine hemoglobin (pPolyHb) in an exchange transfusion model. Each of two groups of rats received a volume of pPolyHb or hetastarch that equalled 120-140% of estimated total blood volume (70 ml/kg) exchange transfusion. The results showed pPolyHb retained hemodynamic stability and exhibited superior volume expansion capability. Furthermore, pPolyHb effectively reverse anaerobic metabolism caused by a large amount of volume exchange. In comparison with hetastarch, pPolyHb increased blood oxygen content and tissue oxygenation. All these properties contribute to a higher effectiveness in sustaining the lives of rats in pPolyHb group.

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Year:  2011        PMID： 21381891      PMCID： PMC3566227          DOI： 10.3109/10731199.2011.559584

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  14 in total

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  1 in total

1.  Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute.

Authors:  Hongli Zhu; Kunping Yan; Xiaodong Dang; He Huang; Erfang Chen; Bang Chen; Chao Luo; Thomas Ming Swi Chang; Penggao Dai; Chao Chen
Journal:  Artif Cells Blood Substit Immobil Biotechnol       Date:  2011-12
  1 in total

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