OBJECTIVE: Renal function is influenced by thyroid status. Therefore, this study was done to determine the relationship between renal function and different degrees of thyroid dysfunction. DESIGN AND METHODS: Thyroid and kidney function tests were analyzed in 47 patients with overt (TSH ≥ 10.0 μIU/L) and 77 patients with subclinical hypothyroidism (TSH 6.0-9.9 μIU/L) in a cross-sectional study. These were compared with 120 age- and sex-matched euthyroid controls. RESULTS: Overt hypothyroid subjects showed significantly raised serum urea, creatinine and uric acid levels as compared to controls whereas subclinical hypothyroid patients showed significant increased levels of serum urea and creatinine levels. TSH showed significant positive correlation with creatinine and uric acid values and, fT4 had a negative correlation with uric acid in overt hypothyroidism. CONCLUSION: Hypothyroid state is associated with significant derangement in biochemical parameters of renal function. Hence the renal function should be regularly monitored in hypothyroid patients.
OBJECTIVE: Renal function is influenced by thyroid status. Therefore, this study was done to determine the relationship between renal function and different degrees of thyroid dysfunction. DESIGN AND METHODS: Thyroid and kidney function tests were analyzed in 47 patients with overt (TSH ≥ 10.0 μIU/L) and 77 patients with subclinical hypothyroidism (TSH 6.0-9.9 μIU/L) in a cross-sectional study. These were compared with 120 age- and sex-matched euthyroid controls. RESULTS: Overt hypothyroid subjects showed significantly raised serum urea, creatinine and uric acid levels as compared to controls whereas subclinical hypothyroidpatients showed significant increased levels of serum urea and creatinine levels. TSH showed significant positive correlation with creatinine and uric acid values and, fT4 had a negative correlation with uric acid in overt hypothyroidism. CONCLUSION:Hypothyroid state is associated with significant derangement in biochemical parameters of renal function. Hence the renal function should be regularly monitored in hypothyroidpatients.
Authors: Dong Ho Shin; Mi Jung Lee; Hye Sun Lee; Hyung Jung Oh; Kwang Il Ko; Chan Ho Kim; Fa Mee Doh; Hyang Mo Koo; Hyoung Rae Kim; Jae Hyun Han; Jung Tak Park; Seung Hyeok Han; Tae-Hyun Yoo; Shin-Wook Kang Journal: Thyroid Date: 2013-05-28 Impact factor: 6.568
Authors: Enise Bagci; Marjolein Heijlen; Lucia Vergauwen; An Hagenaars; Anne M Houbrechts; Camila V Esguerra; Ronny Blust; Veerle M Darras; Dries Knapen Journal: PLoS One Date: 2015-04-09 Impact factor: 3.240