N-(4-Chloro-phen-yl)-4-ethyl-piperazine-1-carboxamide.

In the title mol-ecule, C(13)H(18)ClN(3)O, the piperazine ring has a chair conformation. In the crystal, mol-ecules are linked into chains along [100] by N-H⋯O hydrogen bonds.

Related literature

For applications of carboxamide compounds, see: Arrieta et al. (2007 ▶). For a related structure, see: Li (2011 ▶).

Experimental

Crystal data

C13H18ClN3O

M = 267.75

Orthorhombic,

a = 9.5546 (19) Å

b = 10.910 (2) Å

c = 26.477 (5) Å

V = 2760.1 (10) Å3

Z = 8

Mo Kα radiation

μ = 0.27 mm−1

T = 293 K

0.25 × 0.22 × 0.21 mm

Data collection

Bruker SMART CCD diffractometer

24955 measured reflections

3167 independent reflections

1720 reflections with I > 2σ(I)

R int = 0.079

Refinement

R[F 2 > 2σ(F 2)] = 0.061

wR(F 2) = 0.187

S = 1.00

3167 reflections

168 parameters

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.27 e Å−3

Δρmin = −0.27 e Å−3

Data collection: SMART (Bruker, 1997 ▶); cell refinement: SAINT (Bruker, 1997 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL.

Crystal structure: contains datablock(s) global, I. DOI: 10.1107/S1600536811035331/lh5326sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536811035331/lh5326Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C13H18ClN3O	F(000) = 1136
Mr = 267.75	Dx = 1.289 Mg m−3
Orthorhombic, Pbca	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2ab	Cell parameters from 1720 reflections
a = 9.5546 (19) Å	θ = 3.2–27.2°
b = 10.910 (2) Å	µ = 0.27 mm−1
c = 26.477 (5) Å	T = 293 K
V = 2760.1 (10) Å3	Block, colorless
Z = 8	0.25 × 0.22 × 0.21 mm

Bruker SMART CCD diffractometer	1720 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	Rint = 0.079
graphite	θmax = 27.5°, θmin = 3.1°
φ and ω scans	h = −11→12
24955 measured reflections	k = −14→14
3167 independent reflections	l = −34→33

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.061	H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.187	w = 1/[σ2(Fo2) + (0.1045P)2] where P = (Fo2 + 2Fc2)/3
S = 1.00	(Δ/σ)max < 0.001
3167 reflections	Δρmax = 0.27 e Å−3
168 parameters	Δρmin = −0.27 e Å−3
0 restraints	Extinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.021 (3)

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
Cl1	0.12528 (9)	0.54490 (8)	0.41931 (3)	0.0847 (4)
O1	0.14283 (15)	0.18919 (18)	0.21930 (6)	0.0616 (5)
N3	0.3536 (2)	0.2579 (2)	0.24861 (7)	0.0514 (6)
C8	0.2986 (2)	0.3286 (2)	0.28864 (8)	0.0458 (6)
N2	0.34171 (19)	0.1241 (2)	0.18146 (8)	0.0580 (6)
C13	0.3594 (2)	0.3193 (2)	0.33612 (9)	0.0542 (6)
H13A	0.4350	0.2671	0.3412	0.065*
N1	0.4083 (2)	0.1241 (2)	0.07662 (7)	0.0644 (7)
C11	0.1940 (3)	0.4637 (2)	0.36844 (9)	0.0567 (7)
C12	0.3070 (3)	0.3881 (3)	0.37613 (9)	0.0596 (7)
H12A	0.3482	0.3829	0.4079	0.072*
C10	0.1353 (3)	0.4758 (3)	0.32123 (10)	0.0590 (7)
H10A	0.0605	0.5290	0.3163	0.071*
C7	0.2716 (2)	0.1909 (2)	0.21612 (8)	0.0483 (6)
C9	0.1878 (2)	0.4087 (2)	0.28136 (9)	0.0547 (6)
H9A	0.1486	0.4173	0.2494	0.066*
C6	0.4827 (3)	0.2016 (3)	0.11215 (10)	0.0652 (7)
H6A	0.4382	0.2815	0.1134	0.078*
H6B	0.5782	0.2129	0.1006	0.078*
C4	0.2660 (3)	0.0469 (3)	0.14571 (9)	0.0639 (7)
H4A	0.1702	0.0367	0.1571	0.077*
H4B	0.3094	−0.0334	0.1443	0.077*
C5	0.4841 (2)	0.1467 (3)	0.16426 (9)	0.0612 (7)
H5A	0.5360	0.0703	0.1638	0.073*
H5B	0.5305	0.2023	0.1874	0.073*
C3	0.2667 (3)	0.1030 (3)	0.09430 (10)	0.0707 (8)
H3B	0.2187	0.0490	0.0709	0.085*
H3C	0.2164	0.1802	0.0952	0.085*
C2	0.4049 (4)	0.1795 (4)	0.02561 (12)	0.0997 (12)
H2A	0.3649	0.2610	0.0280	0.120*
H2B	0.3440	0.1308	0.0042	0.120*
C1	0.5445 (4)	0.1884 (5)	0.00140 (12)	0.1227 (16)
H1A	0.5349	0.2248	−0.0314	0.184*
H1B	0.5840	0.1079	−0.0019	0.184*
H1C	0.6048	0.2382	0.0219	0.184*
H3A	0.435 (3)	0.236 (2)	0.2526 (8)	0.053 (7)*

	U11	U22	U33	U12	U13	U23
Cl1	0.0886 (6)	0.0831 (6)	0.0824 (6)	0.0078 (4)	0.0226 (4)	−0.0221 (4)
O1	0.0337 (8)	0.0846 (14)	0.0665 (11)	−0.0008 (8)	0.0028 (7)	−0.0060 (9)
N3	0.0335 (10)	0.0646 (14)	0.0561 (12)	0.0059 (9)	−0.0007 (8)	−0.0081 (10)
C8	0.0382 (11)	0.0471 (14)	0.0521 (13)	−0.0021 (10)	0.0039 (9)	0.0014 (10)
N2	0.0406 (10)	0.0713 (16)	0.0622 (13)	−0.0072 (10)	0.0060 (9)	−0.0169 (11)
C13	0.0484 (13)	0.0530 (16)	0.0613 (15)	0.0056 (11)	−0.0028 (11)	0.0003 (12)
N1	0.0520 (12)	0.0864 (18)	0.0547 (12)	−0.0125 (12)	−0.0010 (9)	−0.0015 (11)
C11	0.0547 (14)	0.0511 (16)	0.0643 (15)	−0.0002 (12)	0.0145 (12)	−0.0034 (12)
C12	0.0600 (15)	0.0637 (18)	0.0552 (14)	−0.0045 (13)	0.0019 (11)	−0.0056 (12)
C10	0.0504 (14)	0.0499 (16)	0.0766 (17)	0.0083 (11)	0.0075 (12)	0.0008 (13)
C7	0.0386 (12)	0.0567 (15)	0.0496 (12)	0.0009 (11)	0.0008 (10)	0.0032 (11)
C9	0.0488 (13)	0.0554 (16)	0.0597 (14)	0.0032 (12)	0.0002 (11)	0.0063 (12)
C6	0.0466 (13)	0.075 (2)	0.0737 (16)	−0.0132 (13)	0.0069 (12)	−0.0094 (15)
C4	0.0510 (14)	0.075 (2)	0.0658 (15)	−0.0186 (13)	0.0059 (12)	−0.0164 (13)
C5	0.0380 (12)	0.084 (2)	0.0618 (15)	0.0002 (12)	−0.0005 (11)	−0.0181 (13)
C3	0.0469 (14)	0.096 (2)	0.0691 (17)	−0.0125 (15)	−0.0036 (12)	−0.0090 (16)
C2	0.083 (2)	0.144 (4)	0.072 (2)	−0.015 (2)	−0.0036 (17)	0.023 (2)
C1	0.097 (3)	0.194 (5)	0.077 (2)	−0.033 (3)	0.0140 (19)	0.021 (2)

Cl1—C11	1.741 (2)	C10—H10A	0.9300
O1—C7	1.233 (3)	C9—H9A	0.9300
N3—C7	1.374 (3)	C6—C5	1.504 (4)
N3—C8	1.413 (3)	C6—H6A	0.9700
N3—H3A	0.82 (3)	C6—H6B	0.9700
C8—C9	1.386 (3)	C4—C3	1.492 (4)
C8—C13	1.389 (3)	C4—H4A	0.9700
N2—C7	1.350 (3)	C4—H4B	0.9700
N2—C5	1.456 (3)	C5—H5A	0.9700
N2—C4	1.458 (3)	C5—H5B	0.9700
C13—C12	1.391 (3)	C3—H3B	0.9700
C13—H13A	0.9300	C3—H3C	0.9700
N1—C3	1.450 (3)	C2—C1	1.482 (5)
N1—C6	1.451 (3)	C2—H2A	0.9700
N1—C2	1.480 (4)	C2—H2B	0.9700
C11—C12	1.374 (4)	C1—H1A	0.9600
C11—C10	1.377 (3)	C1—H1B	0.9600
C12—H12A	0.9300	C1—H1C	0.9600
C10—C9	1.379 (3)
C7—N3—C8	123.20 (19)	N1—C6—H6B	109.3
C7—N3—H3A	117.5 (17)	C5—C6—H6B	109.3
C8—N3—H3A	114.8 (16)	H6A—C6—H6B	108.0
C9—C8—C13	119.4 (2)	N2—C4—C3	110.7 (2)
C9—C8—N3	121.6 (2)	N2—C4—H4A	109.5
C13—C8—N3	118.9 (2)	C3—C4—H4A	109.5
C7—N2—C5	125.8 (2)	N2—C4—H4B	109.5
C7—N2—C4	120.42 (19)	C3—C4—H4B	109.5
C5—N2—C4	111.01 (18)	H4A—C4—H4B	108.1
C8—C13—C12	120.0 (2)	N2—C5—C6	110.24 (19)
C8—C13—H13A	120.0	N2—C5—H5A	109.6
C12—C13—H13A	120.0	C6—C5—H5A	109.6
C3—N1—C6	109.9 (2)	N2—C5—H5B	109.6
C3—N1—C2	109.8 (2)	C6—C5—H5B	109.6
C6—N1—C2	111.4 (2)	H5A—C5—H5B	108.1
C12—C11—C10	120.9 (2)	N1—C3—C4	111.3 (2)
C12—C11—Cl1	119.17 (19)	N1—C3—H3B	109.4
C10—C11—Cl1	120.0 (2)	C4—C3—H3B	109.4
C11—C12—C13	119.6 (2)	N1—C3—H3C	109.4
C11—C12—H12A	120.2	C4—C3—H3C	109.4
C13—C12—H12A	120.2	H3B—C3—H3C	108.0
C11—C10—C9	119.7 (2)	N1—C2—C1	113.7 (3)
C11—C10—H10A	120.1	N1—C2—H2A	108.8
C9—C10—H10A	120.1	C1—C2—H2A	108.8
O1—C7—N2	122.2 (2)	N1—C2—H2B	108.8
O1—C7—N3	122.3 (2)	C1—C2—H2B	108.8
N2—C7—N3	115.43 (19)	H2A—C2—H2B	107.7
C10—C9—C8	120.4 (2)	C2—C1—H1A	109.5
C10—C9—H9A	119.8	C2—C1—H1B	109.5
C8—C9—H9A	119.8	H1A—C1—H1B	109.5
N1—C6—C5	111.5 (2)	C2—C1—H1C	109.5
N1—C6—H6A	109.3	H1A—C1—H1C	109.5
C5—C6—H6A	109.3	H1B—C1—H1C	109.5

D—H···A	D—H	H···A	D···A	D—H···A
N3—H3A···O1i	0.82 (3)	2.18 (3)	2.986 (3)	167 (2)

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N3—H3A⋯O1i	0.82 (3)	2.18 (3)	2.986 (3)	167 (2)

Symmetry code: (i) .