Literature DB >> 2205839

A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes.

S M Robbins1, V V Suttorp, G Weeks, G B Spiegelman.   

Abstract

The cellular slime mold Dictyostelium discoideum contains two ras genes, DdrasG and Ddras that are differentially expressed during development. We have characterized a gene that hybridized to both Ddras and DdrasG under low, but not under high stringency conditions. The deduced amino acid sequence is highly conserved with respect to the human rap (Krev-1, smg21) proteins and the corresponding gene has been designated Ddrap1. The Ddrap1 gene is expressed at all stages during development but is expressed maximally during the aggregation and culmination periods when the expression of Ddras and DdrasG is declining. During vegetative growth and early development Ddrap1 cDNA hybridizes to a single mRNA of 1.1 kb. As development progresses the level of this mRNA declines and messages of 1.0 and 1.3 kb appear.

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Mesh：

Year:  1990        PMID： 2205839      PMCID： PMC332150          DOI： 10.1093/nar/18.17.5265

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  24 in total

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Authors:  C J Der; T Finkel; G M Cooper
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4.  Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.

Authors:  C D Reymond; R H Gomer; M C Mehdy; R A Firtel
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5.  Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.

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6.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

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7.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
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8.  Regulation of a ras-related protein during development of Dictyostelium discoideum.

Authors:  T Pawson; T Amiel; E Hinze; N Auersperg; N Neave; A Sobolewski; G Weeks
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  RNA in cytoplasmic and nuclear fractions of cellular slime mold amebas.

Authors:  S M Cocucci; M Sussman
Journal:  J Cell Biol       Date:  1970-05       Impact factor: 10.539
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  14 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-11-25       Impact factor: 16.971

2.  Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium.

Authors:  Katie Parkinson; Parvin Bolourani; David Traynor; Nicola L Aldren; Robert R Kay; Gerald Weeks; Christopher R L Thompson
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3.  A TaqI RFLP for the human arylsulfatase A gene.

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4.  Uncovering a role for the tail of the Dictyostelium discoideum SadA protein in cell-substrate adhesion.

Authors:  Anthony S Kowal; Rex L Chisholm
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5.  Integrated maps of the chromosomes in Dictyostelium discoideum.

Authors:  W F Loomis; D Welker; J Hughes; D Maghakian; A Kuspa
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9.  REMI-RFLP mapping in the Dictyostelium genome.

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Review 10.  Cytoskeletal regulation by Dictyostelium Ras subfamily proteins.

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