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Literature DB >> 22056667

Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.

Abstract

Histone methylations are highly regulated by site-specific histone methyltransferases and demethylases. In this issue of Genes & Development, Sengoku and Yokoyama (pp. 2266-2277) demonstrate that a novel Zn-binding domain and the Jumonji domain of UTX/KDM6A (Lys demethylase 6A) recognize histone H3 and together function as a substrate specificity determinant for H3K27 demethylation. This study demonstrates the mechanism of site-specific demethylation by UTX/KDM6A and implicates that histone demethylases use diverse methods to accomplish target specificity.

Entities: Chemical Gene

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Year: 2011 PMID： 22056667 PMCID： PMC3219226 DOI： 10.1101/gad.179473.111

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

21 in total

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