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Literature DB >> 22056133

Rewind to recover: dedifferentiation after cardiac injury.

Abstract

In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans. Copyright Â

Entities: Disease Gene Species

Year: 2011 PMID： 22056133 PMCID： PMC4212408 DOI： 10.1016/j.stem.2011.10.011

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

8 in total

1. The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm.

Authors: E E Morrisey; S Musco; M Y Chen; M M Lu; J M Leiden; M S Parmacek
Journal: J Biol Chem Date: 2000-06-30 Impact factor: 5.157

2. Adult cardiac stem cells are multipotent and support myocardial regeneration.

Authors: Antonio P Beltrami; Laura Barlucchi; Daniele Torella; Mathue Baker; Federica Limana; Stefano Chimenti; Hideko Kasahara; Marcello Rota; Ezio Musso; Konrad Urbanek; Annarosa Leri; Jan Kajstura; Bernardo Nadal-Ginard; Piero Anversa
Journal: Cell Date: 2003-09-19 Impact factor: 41.582

3. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

Authors: J D Molkentin; J R Lu; C L Antos; B Markham; J Richardson; J Robbins; S R Grant; E N Olson
Journal: Cell Date: 1998-04-17 Impact factor: 41.582

4. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.

Authors: Thomas Kubin; Jochen Pöling; Sawa Kostin; Praveen Gajawada; Stefan Hein; Wolfgang Rees; Astrid Wietelmann; Minoru Tanaka; Holger Lörchner; Silvia Schimanski; Marten Szibor; Henning Warnecke; Thomas Braun
Journal: Cell Stem Cell Date: 2011-11-04 Impact factor: 24.633

5. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.

Authors: Felix B Engel; Patrick C H Hsieh; Richard T Lee; Mark T Keating
Journal: Proc Natl Acad Sci U S A Date: 2006-10-10 Impact factor: 11.205

6. The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

Authors: Jop H van Berlo; John W Elrod; Maarten M G van den Hoogenhof; Allen J York; Bruce J Aronow; Stephen A Duncan; Jeffery D Molkentin
Journal: Circ Res Date: 2010-08-12 Impact factor: 17.367

7. NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.

Authors: Stefan Gattenlöhner; Christiane Waller; Georg Ertl; Burkhard-Dieter Bültmann; Hans-Konrad Müller-Hermelink; Alexander Marx
Journal: Am J Pathol Date: 2003-09 Impact factor: 4.307

8. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

Authors: Kevin Bersell; Shima Arab; Bernhard Haring; Bernhard Kühn
Journal: Cell Date: 2009-07-23 Impact factor: 41.582

8 in total

1. Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells.

Authors: João Ferreira-Martins; Barbara Ogórek; Donato Cappetta; Alex Matsuda; Sergio Signore; Domenico D'Amario; James Kostyla; Elisabeth Steadman; Noriko Ide-Iwata; Fumihiro Sanada; Grazia Iaffaldano; Sergio Ottolenghi; Toru Hosoda; Annarosa Leri; Jan Kajstura; Piero Anversa; Marcello Rota
Journal: Circ Res Date: 2012-01-24 Impact factor: 17.367

2. Biomimetic microstructure morphology in electrospun fiber mats is critical for maintaining healthy cardiomyocyte phenotype.

Authors: Rutwik Rath; Jung Bok Lee; Truc-Linh Tran; Sean F Lenihan; Cristi L Galindo; Yan Ru Su; Tarek Absi; Leon M Bellan; Douglas B Sawyer; Hak-Joon Sung
Journal: Cell Mol Bioeng Date: 2015-09-08 Impact factor: 2.321

Rewind to recover: dedifferentiation after cardiac injury.

1. The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm.

2. Adult cardiac stem cells are multipotent and support myocardial regeneration.

3. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

4. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.

5. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.

6. The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

7. NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.

8. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

1. Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells.

2. Biomimetic microstructure morphology in electrospun fiber mats is critical for maintaining healthy cardiomyocyte phenotype.

Review 3. Regenerating new heart with stem cells.

Review 4. Origin of cardiomyocytes in the adult heart.

Review 5. The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts.

Review 6. Mechanisms of myocardial regeneration.

7. Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

8. Developmental origin of postnatal cardiomyogenic progenitor cells.