OBJECTIVE: We investigated whether decreased concentrations of placental growth factor (PlGF) in maternal circulation differentiated placental intrauterine growth restriction (IUGR) from constitutionally small fetuses. Excluding congenital syndromes, infection, and aneuploidy, we assumed IUGR with an abnormal placental pathology to be of placental origin. STUDY DESIGN: The study design included a single site, case-control study of 16 cases (9 placental IUGR, 7 constitutionally small) and 79 normal controls with singleton pregnancies. Plasma PlGF was measured by Triage PlGF immunoassay according to the product insert. A positive PlGF test was defined as a concentration less than the fifth percentile for gestational age for normal pregnancy. RESULTS: A positive PlGF test was found in 9 of 9 placental IUGR cases, 1 of 7 constitutionally small fetuses, and 4 of 79 controls (P < .0001). PlGF identified placental IUGR from constitutionally small fetuses with 100% sensitivity and 86% specificity (P = .0009). CONCLUSION: These preliminary data suggest PlGF may identify placental IUGR antenatally.
OBJECTIVE: We investigated whether decreased concentrations of placental growth factor (PlGF) in maternal circulation differentiated placental intrauterine growth restriction (IUGR) from constitutionally small fetuses. Excluding congenital syndromes, infection, and aneuploidy, we assumed IUGR with an abnormal placental pathology to be of placental origin. STUDY DESIGN: The study design included a single site, case-control study of 16 cases (9 placental IUGR, 7 constitutionally small) and 79 normal controls with singleton pregnancies. Plasma PlGF was measured by Triage PlGF immunoassay according to the product insert. A positive PlGF test was defined as a concentration less than the fifth percentile for gestational age for normal pregnancy. RESULTS: A positive PlGF test was found in 9 of 9 placental IUGR cases, 1 of 7 constitutionally small fetuses, and 4 of 79 controls (P < .0001). PlGF identified placental IUGR from constitutionally small fetuses with 100% sensitivity and 86% specificity (P = .0009). CONCLUSION: These preliminary data suggest PlGF may identify placental IUGR antenatally.
Authors: Jennifer A Hutcheon; Geir W Jacobsen; Michael S Kramer; Marit Martinussen; Robert W Platt Journal: Am J Epidemiol Date: 2016-06-02 Impact factor: 4.897
Authors: Anne Marie Darling; Chloe R McDonald; Andrea L Conroy; Kyla T Hayford; W Conrad Liles; Molin Wang; Said Aboud; Willy S Urassa; Kevin C Kain; Wafaie W Fawzi Journal: Am J Obstet Gynecol Date: 2014-05-29 Impact factor: 8.661
Authors: Hong Wa Yung; Myriam Hemberger; Erica D Watson; Claire E Senner; Carolyn P Jones; Randal J Kaufman; D Stephen Charnock-Jones; Graham J Burton Journal: J Pathol Date: 2012-09-28 Impact factor: 7.996
Authors: Philip J Dutton; Lynne K Warrander; Stephen A Roberts; Giovanna Bernatavicius; Louise M Byrd; David Gaze; Josh Kroll; Rebecca L Jones; Colin P Sibley; J Frederik Frøen; Alexander E P Heazell Journal: PLoS One Date: 2012-07-11 Impact factor: 3.240
Authors: Lucy E Higgins; Nicolas Rey de Castro; Naa Addo; Mark Wareing; Susan L Greenwood; Rebecca L Jones; Colin P Sibley; Edward D Johnstone; Alexander E P Heazell Journal: PLoS One Date: 2015-06-29 Impact factor: 3.240