OBJECTIVE: α-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of α-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, the role of α-klotho during pregnancy remains largely unknown. The aim of this study was to determine whether maternal plasma concentration of α-klotho changes during pregnancy and evaluate its expression in pregnancies complicated by small for gestational age (SGA) and/or preeclampsia (PE). STUDY DESIGN: This cross-sectional study included patients in the following groups: (1) non pregnant women (n = 37); (2) uncomplicated pregnancy (n = 130); (3) PE without an SGA neonate (PE; n = 58); (4) PE with an SGA neonate (PE and SGA; n = 52); and (5) SGA neonate without PE (SGA; n = 52). Plasma concentrations of α-klotho were determined by ELISA. RESULTS: The median plasma α-klotho concentration was higher in pregnant than in non-pregnant women. Among women with an uncomplicated pregnancy, the median plasma concentration of α-klotho increased as a function of gestational age (Spearman Rho = 0.2; p = 0.006). The median (interquartile range) plasma concentration of α-klotho in women with PE and SGA [947.6 (762-2013) pg/mL] and SGA without PE [1000 (585-1567) pg/mL] were 21% and 17% lower than that observed in women with an uncomplicated pregnancy [1206.6 (894-2012) pg/mL], (p = 0.005 and p = 0.02), respectively. Additionally, there were no significant differences in the median plasma concentration of α-klotho between uncomplicated pregnancies and women with PE without an SGA neonate (p = 0.5). CONCLUSION: Maternal plasma concentration of α-klotho was higher during pregnancy than in a non-pregnant state. Moreover, the median maternal plasma concentration of α-klotho was lower in mothers who delivered an SGA neonate than in those with an uncomplicated pregnancy regardless of the presence or absence of PE.
OBJECTIVE: α-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of α-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, the role of α-klotho during pregnancy remains largely unknown. The aim of this study was to determine whether maternal plasma concentration of α-klotho changes during pregnancy and evaluate its expression in pregnancies complicated by small for gestational age (SGA) and/or preeclampsia (PE). STUDY DESIGN: This cross-sectional study included patients in the following groups: (1) non pregnant women (n = 37); (2) uncomplicated pregnancy (n = 130); (3) PE without an SGA neonate (PE; n = 58); (4) PE with an SGA neonate (PE and SGA; n = 52); and (5) SGA neonate without PE (SGA; n = 52). Plasma concentrations of α-klotho were determined by ELISA. RESULTS: The median plasma α-klotho concentration was higher in pregnant than in non-pregnant women. Among women with an uncomplicated pregnancy, the median plasma concentration of α-klotho increased as a function of gestational age (Spearman Rho = 0.2; p = 0.006). The median (interquartile range) plasma concentration of α-klotho in women with PE and SGA [947.6 (762-2013) pg/mL] and SGA without PE [1000 (585-1567) pg/mL] were 21% and 17% lower than that observed in women with an uncomplicated pregnancy [1206.6 (894-2012) pg/mL], (p = 0.005 and p = 0.02), respectively. Additionally, there were no significant differences in the median plasma concentration of α-klotho between uncomplicated pregnancies and women with PE without an SGA neonate (p = 0.5). CONCLUSION: Maternal plasma concentration of α-klotho was higher during pregnancy than in a non-pregnant state. Moreover, the median maternal plasma concentration of α-klotho was lower in mothers who delivered an SGA neonate than in those with an uncomplicated pregnancy regardless of the presence or absence of PE.
Authors: K Mori; K Yahata; M Mukoyama; T Suganami; H Makino; T Nagae; H Masuzaki; Y Ogawa; A Sugawara; Y Nabeshima; K Nakao Journal: Biochem Biophys Res Commun Date: 2000-11-30 Impact factor: 3.575
Authors: Hong-wa Yung; Stefania Calabrese; Debby Hynx; Brian A Hemmings; Irene Cetin; D Stephen Charnock-Jones; Graham J Burton Journal: Am J Pathol Date: 2008-06-26 Impact factor: 4.307
Authors: Tinnakorn Chaiworapongsa; Roberto Romero; Francesca Gotsch; Jimmy Espinoza; Jyh Kae Nien; Luis Goncalves; Samuel Edwin; Yeon Mee Kim; Offer Erez; Juan Pedro Kusanovic; Beth L Pineles; Zoltan Papp; Sonia Hassan Journal: J Matern Fetal Neonatal Med Date: 2008-01
Authors: Matthew H Loichinger; Dena Towner; Karen S Thompson; Hyeong Jun Ahn; Gillian D Bryant-Greenwood Journal: Placenta Date: 2016-03-08 Impact factor: 3.481
Authors: Andrew D Franklin; Juanita Saqibuddin; Kelli Stephens; Robert Birkett; Lily Marsden; Linda M Ernst; Karen K Mestan Journal: Placenta Date: 2019-08-30 Impact factor: 3.481
Authors: Sunil Batlahally; Andrew Franklin; Andreas Damianos; Jian Huang; Pingping Chen; Mayank Sharma; Joanne Duara; Divya Keerthy; Ronald Zambrano; Lina A Shehadeh; Eliana C Martinez; Marissa J DeFreitas; Shathiyah Kulandavelu; Carolyn L Abitbol; Michael Freundlich; Rosemeire M Kanashiro-Takeuchi; Augusto Schmidt; Merline Benny; Shu Wu; Karen K Mestan; Karen C Young Journal: Sci Rep Date: 2020-07-23 Impact factor: 4.379
Authors: Anna Kajdy; Jan Modzelewski; Aneta Cymbaluk-Płoska; Ewa Kwiatkowska; Magdalena Bednarek-Jędrzejek; Dariusz Borowski; Katarzyna Stefańska; Michał Rabijewski; Andrzej Torbé; Sebastian Kwiatkowski Journal: Int J Mol Sci Date: 2021-04-18 Impact factor: 5.923