| Literature DB >> 22055203 |
Fatih Sonmez1, Sedat Sevmezler, Alparslan Atahan, Mustafa Ceylan, Dudu Demir, Nahit Gencer, Oktay Arslan, Mustafa Kucukislamoglu.
Abstract
A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity.Entities:
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Year: 2011 PMID： 22055203 DOI： 10.1016/j.bmcl.2011.09.130
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823