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Literature DB >> 22055180

Unraveling a connection between DNA demethylation repair and cancer.

Abstract

In this issue of Molecular Cell, Dango and Mosammaparast discover that the human oxidative demethylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine lesions from ssDNA and that specific cancer cell lines are dependent on this activity for proliferation (Dango et al., 2011). Copyright Â

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 22055180 PMCID： PMC5025764 DOI： 10.1016/j.molcel.2011.10.009

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli.

Authors: Pål Ø Falnes; Rune F Johansen; Erling Seeberg
Journal: Nature Date: 2002-09-12 Impact factor: 49.962

2. Contribution of transcription-coupled DNA repair to MMS-induced mutagenesis in E. coli strains deficient in functional AlkB protein.

Authors: Michał Wrzesiński; Jadwiga Nieminuszczy; Anna Sikora; Damian Mielecki; Aleksandra Chojnacka; Marek Kozłowski; Joanna Krwawicz; Elzbieta Grzesiuk
Journal: Mutat Res Date: 2010-02-21 Impact factor: 2.433

Review 3. Repair of alkylated DNA: recent advances.

Authors: Barbara Sedgwick; Paul A Bates; Johanna Paik; Susan C Jacobs; Tomas Lindahl
Journal: DNA Repair (Amst) Date: 2006-11-16

4. Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.

Authors: Jeanette Ringvoll; Line M Nordstrand; Cathrine B Vågbø; Vivi Talstad; Karen Reite; Per Arne Aas; Knut H Lauritzen; Nina Beate Liabakk; Alexandra Bjørk; Richard William Doughty; Pål Ø Falnes; Hans E Krokan; Arne Klungland
Journal: EMBO J Date: 2006-04-27 Impact factor: 11.598

5. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.

Authors: Sebastian Dango; Nima Mosammaparast; Mathew E Sowa; Li-Jun Xiong; Feizhen Wu; Keyjung Park; Mark Rubin; Steve Gygi; J Wade Harper; Yang Shi
Journal: Mol Cell Date: 2011-11-04 Impact factor: 17.970

6. Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells.

Authors: Wei Gao; Leijia Li; Ping Xu; Jingyuan Fang; Shudong Xiao; Shengliang Chen
Journal: J Gastroenterol Hepatol Date: 2011-03 Impact factor: 4.029

7. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.

Authors: Sarah C Trewick; Timothy F Henshaw; Robert P Hausinger; Tomas Lindahl; Barbara Sedgwick
Journal: Nature Date: 2002-09-12 Impact factor: 49.962

8. ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.

Authors: M Tasaki; K Shimada; H Kimura; K Tsujikawa; N Konishi
Journal: Br J Cancer Date: 2011-02-01 Impact factor: 7.640

9. Identification of a novel, widespread, and functionally important PCNA-binding motif.

Authors: Karin M Gilljam; Emadoldin Feyzi; Per A Aas; Mirta M L Sousa; Rebekka Müller; Cathrine B Vågbø; Tara C Catterall; Nina B Liabakk; Geir Slupphaug; Finn Drabløs; Hans E Krokan; Marit Otterlei
Journal: J Cell Biol Date: 2009-09-07 Impact factor: 10.539

10. Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria.

Authors: Erwin van den Born; Anders Bekkelund; Marivi N Moen; Marina V Omelchenko; Arne Klungland; Pål Ø Falnes
Journal: Nucleic Acids Res Date: 2009-11 Impact factor: 16.971