Literature DB >> 2205491

Joint actions of environmental nonionizing electromagnetic fields and chemical pollution in cancer promotion.

W R Adey1.   

Abstract

Studies of environmental electromagnetic (EM) field interactions in tissues have contributed to a new understanding of both normal growth and the biology of cancer in cell growth. From cancer research comes a floodtide of new knowledge about the disruption of communication by cancer-promoting chemicals with an onset of unregulated growth. Bioelectromagnetic research reveals clear evidence of joint actions at cell membranes of chemical cancer promoters and environmental electromagnetic fields. The union of these two disciplines has resulted in the first major new approach to tumor formation in 75 years, directing attention to dysfunctions in inward and outward streams of signals at cell membranes, rather than to damage DNA in cell nuclei, and to synergic actions of chemical pollutants and environmental electromagnetic fields. We are witnesses and, in great measure, participants in one of the great revolutions in the history of biology. In little more than a century, we have moved from organs, to tissues, to cells, and finally to the molecules that are the elegant fabric of living tissues. Today, we stand at a new frontier. It may be more difficult to comprehend, but it is far more significant; for it is at the atomic level, rather than the molecular, that physical, rather than chemical, processes appear to shape the flow of signals that are at the essence of living matter. To pursue these problems in the environment and in the laboratory, our needs for further research with appropriate budgets are great.(ABSTRACT TRUNCATED AT 250 WORDS)

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Year:  1990        PMID: 2205491      PMCID: PMC1567752          DOI: 10.1289/ehp.9086297

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN: 0091-6765            Impact factor:   9.031


  40 in total

Review 1.  Receptor-mediated action without receptor occupancy: a function for cell-cell communication in ovarian follicles.

Authors:  W H Fletcher; C V Byus; D A Walsh
Journal:  Adv Exp Med Biol       Date:  1987       Impact factor: 2.622

2.  Mechanisms of tumor promotion: possible role of inhibited intercellular communication.

Authors:  J E Trosko
Journal:  Eur J Cancer Clin Oncol       Date:  1987-06

3.  Microwaves: the risks of risk research.

Authors:  K R Foster; W F Pickard
Journal:  Nature       Date:  1987 Dec 10-16       Impact factor: 49.962

4.  Effects of microwaves on cells and molecules.

Authors:  R Adey
Journal:  Nature       Date:  1988-06-02       Impact factor: 49.962

5.  A calcium-dependent mechanism for synapse and nerve cell membrane modulation.

Authors:  H Hydén
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

6.  The effects of low-energy 60-Hz environmental electromagnetic fields upon the growth-related enzyme ornithine decarboxylase.

Authors:  C V Byus; S E Pieper; W R Adey
Journal:  Carcinogenesis       Date:  1987-10       Impact factor: 4.944

7.  Brain tumor mortality risk among men with electrical and electronics jobs: a case-control study.

Authors:  T L Thomas; P D Stolley; A Stemhagen; E T Fontham; M L Bleecker; P A Stewart; R N Hoover
Journal:  J Natl Cancer Inst       Date:  1987-08       Impact factor: 13.506

8.  Case-control study of childhood cancer and exposure to 60-Hz magnetic fields.

Authors:  D A Savitz; H Wachtel; F A Barnes; E M John; J G Tvrdik
Journal:  Am J Epidemiol       Date:  1988-07       Impact factor: 4.897

9.  The fluid mosaic model of the structure of cell membranes.

Authors:  S J Singer; G L Nicolson
Journal:  Science       Date:  1972-02-18       Impact factor: 47.728

10.  Reproduction and development in rats chronologically exposed to 60-Hz electric fields.

Authors:  D N Rommereim; W T Kaune; R L Buschbom; R D Phillips; M R Sikov
Journal:  Bioelectromagnetics       Date:  1987       Impact factor: 2.010

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  5 in total

Review 1.  Environmental risk factors for primary malignant brain tumors: a review.

Authors:  M Wrensch; M L Bondy; J Wiencke; M Yost
Journal:  J Neurooncol       Date:  1993-07       Impact factor: 4.130

2.  Incidence of cancer in persons with occupational exposure to electromagnetic fields in Denmark.

Authors:  P Guénel; P Raskmark; J B Andersen; E Lynge
Journal:  Br J Ind Med       Date:  1993-08

Review 3.  Magnetic fields and cancer: animal and cellular evidence--an overview.

Authors:  B Holmberg
Journal:  Environ Health Perspect       Date:  1995-03       Impact factor: 9.031

4.  Biologically based epidemiological studies of electric power and cancer.

Authors:  R G Stevens
Journal:  Environ Health Perspect       Date:  1993-12       Impact factor: 9.031

Review 5.  Human adverse reproductive outcomes and electromagnetic field exposures: review of epidemiologic studies.

Authors:  G M Shaw; L A Croen
Journal:  Environ Health Perspect       Date:  1993-12       Impact factor: 9.031

  5 in total

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