Literature DB >> 22053974

CCL5: a double-edged sword in host defense against the hepatitis C virus.

Antonios Katsounas1, Joerg F Schlaak, Richard A Lempicki.   

Abstract

C-C motif ligand 5 (CCL5) facilitates induction of chemotaxis in immune cells and activation of hepatic stellate cells (HSC) at sites of liver inflammation during chronic hepatitis C virus (HCV) infection. Importantly, CCL5 participates in the establishment of T-helper 1 responses crucial in controlling liver disease and HCV infection outcome and demonstrates distinct gene expression patterns between the blood and the liver, stressing the importance of immunoregulatory networks differentially functioning between these compartments. This review illustrates the significance of CCL5-dependent pathways in HCV-related immunopathogenesis by elaborating on biological mechanisms interconnecting peripheral and tissue immunology, liver pathology, HSC activation, and interferon-α immunotherapy.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22053974     DOI： 10.3109/08830185.2011.593105

Source DB:  PubMed          Journal:  Int Rev Immunol        ISSN： 0883-0185            Impact factor:   5.311


  14 in total

1.  Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance.

Authors:  Yinan Yao; Ming Yue; Feng Zang; Mei Liu; Haozhi Fan; Lingyun Zhuo; Jingjing Wu; Xueshan Xia; Yue Feng; Peng Huang; Rongbin Yu
Journal:  J Hum Genet       Date:  2018-04-27       Impact factor: 3.172

2.  A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.

Authors:  Ludmila Prokunina-Olsson; Brian Muchmore; Wei Tang; Ruth M Pfeiffer; Heiyoung Park; Harold Dickensheets; Dianna Hergott; Patricia Porter-Gill; Adam Mumy; Indu Kohaar; Sabrina Chen; Nathan Brand; McAnthony Tarway; Luyang Liu; Faruk Sheikh; Jacquie Astemborski; Herbert L Bonkovsky; Brian R Edlin; Charles D Howell; Timothy R Morgan; David L Thomas; Barbara Rehermann; Raymond P Donnelly; Thomas R O'Brien
Journal:  Nat Genet       Date:  2013-01-06       Impact factor: 38.330

3.  Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.

Authors:  Chandrashekhar D Patil; Rahul Suryawanshi; Joshua Ames; Raghuram Koganti; Alex Agelidis; Divya Kapoor; Tejabhiram Yadavalli; Lulia Koujah; Henry C Tseng; Deepak Shukla
Journal:  J Immunol       Date:  2021-12-08       Impact factor: 5.426

4.  Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-κB-Nuclear Translocation.

Authors:  Xia Jiang; Tatsuo Kanda; Shuang Wu; Shingo Nakamoto; Masato Nakamura; Reina Sasaki; Yuki Haga; Takaji Wakita; Hiroshi Shirasawa; Osamu Yokosuka
Journal:  PLoS One       Date:  2015-07-02       Impact factor: 3.240

Review 5.  Platelets and infection - an emerging role of platelets in viral infection.

Authors:  Alice Assinger
Journal:  Front Immunol       Date:  2014-12-18       Impact factor: 7.561

Review 6.  Platelets in inflammation and atherogenesis.

Authors:  Henry M Nording; Peter Seizer; Harald F Langer
Journal:  Front Immunol       Date:  2015-03-06       Impact factor: 7.561

7.  A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.

Authors:  Kara M Pryke; Jinu Abraham; Tina M Sali; Bryan J Gall; Iris Archer; Andrew Liu; Shelly Bambina; Jason Baird; Michael Gough; Marita Chakhtoura; Elias K Haddad; Ilsa T Kirby; Aaron Nilsen; Daniel N Streblow; Alec J Hirsch; Jessica L Smith; Victor R DeFilippis
Journal:  mBio       Date:  2017-05-02       Impact factor: 7.867

8.  Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

Authors:  Francesc Vidal; Miguel López-Dupla; Montserrat Laguno; Sergi Veloso; Josep Mallolas; Javier Murillas; Carmen Cifuentes; Lluis Gallart; Teresa Auguet; Gloria Sampériz; Antoni Payeras; Pilar Hernandez; Mireia Arnedo; Josep Ma Gatell; Cristóbal Richart
Journal:  PLoS One       Date:  2012-11-02       Impact factor: 3.240

9.  Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico.

Authors:  Karina Gonzalez-Aldaco; João R Rebello Pinho; Sonia Roman; Ketti Gleyzer; Nora A Fierro; Leticia Oyakawa; Omar Ramos-Lopez; Rubia A Ferraz Santana; Roberta Sitnik; Arturo Panduro
Journal:  PLoS One       Date:  2016-01-07       Impact factor: 3.240

10.  Association of TNF-α and CCL5 with response to interferon-based therapy in patients with HCV 1 genotype.

Authors:  Dzmitry Danilau; Dzmitry Litvinchuk; Nikita Solovey; Olga Krasko; Igor Karpov
Journal:  Clin Exp Hepatol       Date:  2017-01-20
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.