BACKGROUND: Little is known about the association of obesity and physical activity at young ages with subsequent risk of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: Between 2003 and 2007, we conducted a case-control study in a high-risk population in northeastern Iran. Three hundred ESCC cases and 571 matched controls were recruited. Each individual was shown a standard pictogram, to report body size at ages 15 and 30. Demographic and health-related information, including physical activity at these ages was also collected. RESULTS: In the fully adjusted models, very obese body size (last two pictograms) at age 15 [odds ratio (OR) 3.2, 95% confidence interval (CI) 1.3-7.7] and age 30 (OR 3.1; 95% CI 1.1-8.5) were associated with ESCC in women, but not in men. Sedentary work at age 15 (OR 3.3, 95% CI 1.3-8.3) and 30 (OR 18.2, 95% CI 3.9-86.2) were also associated with ESCC risk in women only. The increased risk in women at age 15 remained high after later reduction in body size, while women who became very obese only at age 30 did not show a significantly increased risk. CONCLUSION: These results highlight the importance of early lifestyle modifications in the context of cancer prevention, particularly in women.
BACKGROUND: Little is known about the association of obesity and physical activity at young ages with subsequent risk of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: Between 2003 and 2007, we conducted a case-control study in a high-risk population in northeastern Iran. Three hundred ESCC cases and 571 matched controls were recruited. Each individual was shown a standard pictogram, to report body size at ages 15 and 30. Demographic and health-related information, including physical activity at these ages was also collected. RESULTS: In the fully adjusted models, very obese body size (last two pictograms) at age 15 [odds ratio (OR) 3.2, 95% confidence interval (CI) 1.3-7.7] and age 30 (OR 3.1; 95% CI 1.1-8.5) were associated with ESCC in women, but not in men. Sedentary work at age 15 (OR 3.3, 95% CI 1.3-8.3) and 30 (OR 18.2, 95% CI 3.9-86.2) were also associated with ESCC risk in women only. The increased risk in women at age 15 remained high after later reduction in body size, while women who became very obese only at age 30 did not show a significantly increased risk. CONCLUSION: These results highlight the importance of early lifestyle modifications in the context of cancer prevention, particularly in women.
Authors: W Guo; W J Blot; J Y Li; P R Taylor; B Q Liu; W Wang; Y P Wu; W Zheng; S M Dawsey; B Li Journal: Int J Epidemiol Date: 1994-06 Impact factor: 7.196
Authors: Arash Etemadi; Christian C Abnet; Farin Kamangar; Farhad Islami; Hooman Khademi; Akram Pourshams; Hossein Poustchi; Mohammad Bagheri; Amir Ali Sohrabpour; Ali Aliasgar; Masoud Khoshnia; Sholom Wacholder; Charles C Matthews; Paul D Pharoah; Paul Brennan; Paolo Boffetta; Reza Malekzadeh; Sanford M Dawsey Journal: Eur J Epidemiol Date: 2014-02-21 Impact factor: 8.082
Authors: Arash Etemadi; Mark G O'Doherty; Neal D Freedman; Albert R Hollenbeck; Sanford M Dawsey; Christian C Abnet Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-29 Impact factor: 4.254
Authors: Michael B Cook; Charles E Matthews; Munira Z Gunja; Zaynah Abid; Neal D Freedman; Christian C Abnet Journal: PLoS One Date: 2013-12-19 Impact factor: 3.240
Authors: Andrew T Kunzmann; Kristian P Mallon; Ruth F Hunter; Chris R Cardwell; Úna C McMenamin; Andrew D Spence; Helen G Coleman Journal: United European Gastroenterol J Date: 2018-06-07 Impact factor: 4.623