BACKGROUND: Squamous cell oesophageal cancer is one of the few neoplasms inversely related to body mass index (BMI). However, it is not clear whether this is due to cancer-related weight loss or to other correlates of leanness. PATIENTS AND METHODS: 395 incident, histologically confirmed cases of squamous cell oesophageal cancer and 1,066 controls, admitted for acute, non-neoplastic diseases, in Italy and Switzerland. Odds ratios (ORs) were derived from multiple logistic regression, including terms for education, tobacco. alcohol, non-alcohol energy, fruit and vegetable intake. RESULTS: The ORs for the lowest vs. the highest quartile of BMI in the year before diagnosis were 2.0 in men, 1.6 in women, and 1.9 (95% confidence interval: 1.3-2.9) in both sexes combined. The association with leanness was stronger in heavy smokers, but was not accounted for by smoking and drinking, nor by differences in diet. Weight change in the decade prior to diagnosis showed no linear association with risk. However, cases were not leaner than controls at age 30 (OR = 0.6 for the lowest BMI quartile) and 50 (OR = 1.1). CONCLUSIONS: Leanness appears to be an indicator of squamous cell oesophageal carcinogenesis. However, low BMI in the distant past was unrelated to oesophageal cancer risk.
BACKGROUND:Squamous cell oesophageal cancer is one of the few neoplasms inversely related to body mass index (BMI). However, it is not clear whether this is due to cancer-related weight loss or to other correlates of leanness. PATIENTS AND METHODS: 395 incident, histologically confirmed cases of squamous cell oesophageal cancer and 1,066 controls, admitted for acute, non-neoplastic diseases, in Italy and Switzerland. Odds ratios (ORs) were derived from multiple logistic regression, including terms for education, tobacco. alcohol, non-alcohol energy, fruit and vegetable intake. RESULTS: The ORs for the lowest vs. the highest quartile of BMI in the year before diagnosis were 2.0 in men, 1.6 in women, and 1.9 (95% confidence interval: 1.3-2.9) in both sexes combined. The association with leanness was stronger in heavy smokers, but was not accounted for by smoking and drinking, nor by differences in diet. Weight change in the decade prior to diagnosis showed no linear association with risk. However, cases were not leaner than controls at age 30 (OR = 0.6 for the lowest BMI quartile) and 50 (OR = 1.1). CONCLUSIONS:Leanness appears to be an indicator of squamous cell oesophageal carcinogenesis. However, low BMI in the distant past was unrelated to oesophageal cancer risk.
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Authors: Mia M Gaudet; Andrew F Olshan; Shu-Chun Chuang; Julien Berthiller; Zuo-Feng Zhang; Jolanta Lissowska; David Zaridze; Deborah M Winn; Qingyi Wei; Renato Talamini; Neolilia Szeszenia-Dabrowska; Erich M Sturgis; Stephen M Schwartz; Peter Rudnai; Jose Eluf-Neto; Joshua Muscat; Hal Morgenstern; Ana Menezes; Elena Matos; Alexandru Bucur; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Sergio Koifman; Karl Kelsey; Rolando Herrero; Richard B Hayes; Silva Franceschi; Victor Wunsch-Filho; Leticia Fernandez; Eleonora Fabianova; Alexander W Daudt; Luigino Dal Maso; Maria Paula Curado; Chu Chen; Xavier Castellsague; Simone Benhamou; Paolo Boffetta; Paul Brennan; Mia Hashibe Journal: Int J Epidemiol Date: 2010-02-01 Impact factor: 7.196
Authors: Yoon Jin Choi; Dong Ho Lee; Kyung Do Han; Hyuk Yoon; Cheol Min Shin; Young Soo Park; Nayoung Kim Journal: Asian Pac J Cancer Prev Date: 2017-07-27