Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sox9 is upstream of microRNA-140 in cartilage.

Literature DB >> 22052544

Sox9 is upstream of microRNA-140 in cartilage.

Yukio Nakamura¹, Xinjun He, Hiroyuki Kato, Shigeyuki Wakitani, Tatsuya Kobayashi, Sumiko Watanabe, Atsumi Iida, Hideaki Tahara, Matthew L Warman, Ramida Watanapokasin, John H Postlethwait.

Abstract

MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 22052544 PMCID： PMC3774128 DOI： 10.1007/s12010-011-9404-y

Source DB: PubMed Journal: Appl Biochem Biotechnol ISSN： 0273-2289 Impact factor: 2.926

28 in total

1. MicroRNA genes are transcribed by RNA polymerase II.

Authors: Yoontae Lee; Minju Kim; Jinju Han; Kyu-Hyun Yeom; Sanghyuk Lee; Sung Hee Baek; V Narry Kim
Journal: EMBO J Date: 2004-09-16 Impact factor: 11.598

2. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts.

Authors: Xinjun He; Yi-Lin Yan; April DeLaurier; John H Postlethwait
Journal: Zebrafish Date: 2011-02-02 Impact factor: 1.985

3. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Authors: Haruhiko Akiyama; Marie-Christine Chaboissier; James F Martin; Andreas Schedl; Benoit de Crombrugghe
Journal: Genes Dev Date: 2002-11-01 Impact factor: 11.361

4. Stages of embryonic development of the zebrafish.

Authors: C B Kimmel; W W Ballard; S R Kimmel; B Ullmann; T F Schilling
Journal: Dev Dyn Date: 1995-07 Impact factor: 3.780

5. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

Authors: E Wright; M R Hargrave; J Christiansen; L Cooper; J Kun; T Evans; U Gangadharan; A Greenfield; P Koopman
Journal: Nat Genet Date: 1995-01 Impact factor: 38.330

6. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene.

Authors: J W Foster; M A Dominguez-Steglich; S Guioli; C Kwok; P A Weller; M Stevanović; J Weissenbach; S Mansour; I D Young; P N Goodfellow
Journal: Nature Date: 1994-12-08 Impact factor: 49.962

7. SOX9-dependent and -independent transcriptional regulation of human cartilage link protein.

Authors: Ikuyo Kou; Shiro Ikegawa
Journal: J Biol Chem Date: 2004-09-28 Impact factor: 5.157

8. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.

Authors: T Wagner; J Wirth; J Meyer; B Zabel; M Held; J Zimmer; J Pasantes; F D Bricarelli; J Keutel; E Hustert; U Wolf; N Tommerup; W Schempp; G Scherer
Journal: Cell Date: 1994-12-16 Impact factor: 41.582

9. Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

Authors: M van de Wetering; H Clevers
Journal: EMBO J Date: 1992-08 Impact factor: 11.598

10. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos.

Authors: C Thisse; B Thisse; T F Schilling; J H Postlethwait
Journal: Development Date: 1993-12 Impact factor: 6.868

35 in total

1. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.

Authors: Satoshi Yamashita; Shigeru Miyaki; Yoshio Kato; Shigetoshi Yokoyama; Tempei Sato; Francisco Barrionuevo; Haruhiko Akiyama; Gerd Scherer; Shuji Takada; Hiroshi Asahara
Journal: J Biol Chem Date: 2012-04-30 Impact factor: 5.157

Review 2. Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases.

Authors: Yuankun Zhai; Suresh C Tyagi; Neetu Tyagi
Journal: Biomed Pharmacother Date: 2017-06-10 Impact factor: 6.529

3. Expression profiling of microRNAs and isomiRs in conventional central chondrosarcoma.

Authors: Antonina Parafioriti; Ingrid Cifola; Clarissa Gissi; Eva Pinatel; Laura Vilardo; Elisabetta Armiraglio; Andrea Di Bernardo; Primo Andrea Daolio; Armando Felsani; Igea D'Agnano; Anna Concetta Berardi
Journal: Cell Death Discov Date: 2020-06-10

Sox9 is upstream of microRNA-140 in cartilage.

1. MicroRNA genes are transcribed by RNA polymerase II.

2. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts.

3. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

4. Stages of embryonic development of the zebrafish.

5. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

6. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene.

7. SOX9-dependent and -independent transcriptional regulation of human cartilage link protein.

8. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.

9. Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

10. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos.

1. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.

Review 2. Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases.

3. Expression profiling of microRNAs and isomiRs in conventional central chondrosarcoma.

4. Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation.

Review 5. Deregulation and therapeutic potential of microRNAs in arthritic diseases.

6. SOX9/miR-130a/CTR1 axis modulates DDP-resistance of cervical cancer cell.

Review 7. Regulation of body growth by microRNAs.

Review 8. MicroRNAs in cartilage development, homeostasis, and disease.

Review 9. MicroRNAs involved in bone formation.

Review 10. MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.