| Literature DB >> 7990924 |
J W Foster1, M A Dominguez-Steglich, S Guioli, C Kwok, P A Weller, M Stevanović, J Weissenbach, S Mansour, I D Young, P N Goodfellow.
Abstract
Induction of testis development in mammals requires the presence of the Y-chromosome gene SRY. This gene must exert its effect by interacting with other genes in the sex-determination pathway. Cloning of a translocation chromosome breakpoint from a sex-reversed patient with campomelic dysplasia, followed by mutation analysis of an adjacent gene, indicates that SOX9, an SRY-related gene, is involved in both bone formation and control of testis development.Entities:
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Year: 1994 PMID： 7990924 DOI： 10.1038/372525a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962