Literature DB >> 22045240

Effluent volume and dialysis dose in CRRT: time for reappraisal.

Etienne Macedo1, Rolando Claure-Del Granado, Ravindra L Mehta.   

Abstract

The results of several studies assessing dialysis dose have dampened the enthusiasm of clinicians for considering dialysis dose as a modifiable factor influencing outcomes in patients with acute kidney injury. Powerful evidence from two large, multicenter trials indicates that increasing the dialysis dose, measured as hourly effluent volume, has no benefit in continuous renal replacement therapy (CRRT). However, some important operational characteristics that affect delivered dose were not evaluated. Effluent volume does not correspond to the actual delivered dose, as a decline in filter efficacy reduces solute removal during therapy. We believe that providing accurate parameters of delivered dose could improve the delivery of a prescribed dose and refine the assessment of the effect of dose on outcomes in critically ill patients treated with CRRT.

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Year:  2011        PMID： 22045240     DOI： 10.1038/nrneph.2011.172

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN： 1759-5061            Impact factor:   28.314


  19 in total

1.  Daily hemodialysis and the outcome of acute renal failure.

Authors:  Helmut Schiffl; Susanne M Lang; Rainald Fischer
Journal:  N Engl J Med       Date:  2002-01-31       Impact factor: 91.245

Review 2.  Current status of dosing and quantification of acute renal replacement therapy. Part 1: mechanisms and consequences of therapy under-delivery.

Authors:  Mark R Marshall
Journal:  Nephrology (Carlton)       Date:  2006-06       Impact factor: 2.506

3.  Effluent volume in continuous renal replacement therapy overestimates the delivered dose of dialysis.

Authors:  Rolando Claure-Del Granado; Etienne Macedo; Glenn M Chertow; Sharon Soroko; Jonathan Himmelfarb; T Alp Ikizler; Emil P Paganini; Ravindra L Mehta
Journal:  Clin J Am Soc Nephrol       Date:  2010-11-29       Impact factor: 8.237

4.  Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates.

Authors:  S Brunet; M Leblanc; D Geadah; D Parent; S Courteau; J Cardinal
Journal:  Am J Kidney Dis       Date:  1999-09       Impact factor: 8.860

5.  Prescribed versus delivered dialysis in acute renal failure patients.

Authors:  J A Evanson; J Himmelfarb; R Wingard; S Knights; Y Shyr; G Schulman; T A Ikizler; R M Hakim
Journal:  Am J Kidney Dis       Date:  1998-11       Impact factor: 8.860

Review 6.  Dose determinants in continuous renal replacement therapy.

Authors:  William R Clark; Joseph E Turk; Michael A Kraus; Dayong Gao
Journal:  Artif Organs       Date:  2003-09       Impact factor: 3.094

7.  Standard versus high-dose CVVHDF for ICU-related acute renal failure.

Authors:  Ashita J Tolwani; Ruth C Campbell; Brenda S Stofan; K Robin Lai; Robert A Oster; Keith M Wille
Journal:  J Am Soc Nephrol       Date:  2008-03-12       Impact factor: 10.121

8.  Intensity of renal support in critically ill patients with acute kidney injury.

Authors:  Paul M Palevsky; Jane Hongyuan Zhang; Theresa Z O'Connor; Glenn M Chertow; Susan T Crowley; Devasmita Choudhury; Kevin Finkel; John A Kellum; Emil Paganini; Roland M H Schein; Mark W Smith; Kathleen M Swanson; B Taylor Thompson; Anitha Vijayan; Suzanne Watnick; Robert A Star; Peter Peduzzi
Journal:  N Engl J Med       Date:  2008-05-20       Impact factor: 91.245

9.  Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury.

Authors:  Sergio Vesconi; Dinna N Cruz; Roberto Fumagalli; Detlef Kindgen-Milles; Gianpaola Monti; Anibal Marinho; Filippo Mariano; Marco Formica; Mariano Marchesi; Robert René; Sergio Livigni; Claudio Ronco
Journal:  Crit Care       Date:  2009-04-15       Impact factor: 9.097

Review 10.  Dialysis dose in acute kidney injury: no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.

Authors:  Claudio Ronco; Dinna Cruz; Helen Oudemans van Straaten; Patrick Honore; Andrew House; Du Bin; Noel Gibney
Journal:  Crit Care       Date:  2008-10-16       Impact factor: 9.097
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  6 in total

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Review 2.  Renal replacement therapy in acute kidney injury.

Authors:  Paul M Palevsky
Journal:  Adv Chronic Kidney Dis       Date:  2013-01       Impact factor: 3.620

Review 3.  Dose of Continuous Renal Replacement Therapy in Critically Ill Patients: A Bona Fide Quality Indicator.

Authors:  Enzo Vásquez Jiménez; Samaya J Anumudu; Javier A Neyra
Journal:  Nephron       Date:  2021-02-04       Impact factor: 2.847

4.  Challenges and pitfalls when implementing renal replacement therapy in the ICU.

Authors:  Ravindra L Mehta
Journal:  Crit Care       Date:  2015-12-18       Impact factor: 9.097

5.  Clinical outcomes and prognostic factors of mortality in liver cirrhosis patients on continuous renal replacement therapy in two tertiary hospitals in Korea.

Authors:  You Hyun Jeon; Il Young Kim; Gum Sook Jang; Sang Heon Song; Eun Young Seong; Dong Won Lee; Soo Bong Lee; Hyo Jin Kim
Journal:  Kidney Res Clin Pract       Date:  2021-08-11

6.  Regional Citrate Anticoagulation for Continuous Kidney Replacement Therapy With Calcium-Containing Solutions: A Cohort Study.

Authors:  Harin Rhee; Brendan Berenger; Ravindra L Mehta; Etienne Macedo
Journal:  Am J Kidney Dis       Date:  2021-03-30       Impact factor: 11.072
  6 in total

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