Literature DB >> 2204157

Beta-galactoside transport in E. coli: a functional dissection of lac permease.

H R Kaback1, E Bibi, P D Roepe.   

Abstract

The polytopic membrane protein lac permease harnesses energy from the electrochemical H+ gradient to transport beta-galactosidases against a concentration gradient. Although high-resolution structural information is still lacking, the permease is thought to possess 12 membrane-spanning alpha-helical segments. Various experimental strategies, including site-directed mutagenesis, have been employed to probe the function of this membrane protein at the molecular level.

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Year:  1990        PMID： 2204157     DOI： 10.1016/0968-0004(90)90020-c

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  18 in total

1.  Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli.

Authors:  M Sahin-Tóth; R L Dunten; A Gonzalez; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

2.  Insertional mutagenesis of hydrophilic domains in the lactose permease of Escherichia coli.

Authors:  E McKenna; D Hardy; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

3.  Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli.

Authors:  E Bibi; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

4.  Organization and stability of a polytopic membrane protein: deletion analysis of the lactose permease of Escherichia coli.

Authors:  E Bibi; G Verner; C Y Chang; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

Review 5.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

6.  High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells.

Authors:  M K Sievert; D S Thiriot; R H Edwards; A E Ruoho
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

7.  Membrane topology model of Escherichia coli alpha-ketoglutarate permease by phoA fusion analysis.

Authors:  W Seol; A J Shatkin
Journal:  J Bacteriol       Date:  1993-01       Impact factor: 3.490

8.  Alamethicin and related peptaibols--model ion channels.

Authors:  M S Sansom
Journal:  Eur Biophys J       Date:  1993       Impact factor: 1.733

9.  Molecular cloning of a maltose transport gene from Bacillus stearothermophilus and its expression in Escherichia coli K-12.

Authors:  E C Liong; T Ferenci
Journal:  Mol Gen Genet       Date:  1994-05-10

10.  Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli.

Authors:  M Sahin-Tóth; M C Lawrence; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205
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