| Literature DB >> 22041057 |
Brian A Sherer1, Kenneth Hull, Oluyinka Green, Gregory Basarab, Sheila Hauck, Pamela Hill, James T Loch, George Mullen, Shanta Bist, Joanna Bryant, Ann Boriack-Sjodin, Jon Read, Nancy DeGrace, Maria Uria-Nickelsen, Ruth N Illingworth, Ann E Eakin.
Abstract
The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochemical activity and other drug-like properties through substitutions to the pyrrole, piperidine, and heterocycle portions of the molecule resulted in pyrrolamides with improved cellular activity and in vivo efficacy.Entities:
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Year: 2011 PMID： 22041057 DOI： 10.1016/j.bmcl.2011.10.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823