PURPOSE: To test whether female subjects in families with cleft lip and/or palate (CL/P) have an increased risk of breast cancer. METHODS: By using the Danish Facial Cleft Registry, we identified female subjects with CL/P, mothers of children with CL/P, and sisters to CL/P cases for the Danish birth cohorts 1911-1975. These subjects were compared with a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977-2005. RESULTS: Examining 48,404 person-years for 1809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases), we found no increased breast cancer risk for either CL/P cases (hazard ratio [HR], 1.23; 95% confidence interval (CI), 0.92-1.63), mothers of children with CL/P (HR, 0.93; 95% CI, 0.80-1.08), or sisters of CL/P cases (HR, 0.94; 95% CI, 0.55-1.60), nor was there any significant differences in age of onset. CONCLUSION: Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and CL/P. However, in this population-based study we were not able to confirm a general increase in the risk of breast cancer among female subjects in families with CL/P.
PURPOSE: To test whether female subjects in families with cleft lip and/or palate (CL/P) have an increased risk of breast cancer. METHODS: By using the Danish Facial Cleft Registry, we identified female subjects with CL/P, mothers of children with CL/P, and sisters to CL/P cases for the Danish birth cohorts 1911-1975. These subjects were compared with a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977-2005. RESULTS: Examining 48,404 person-years for 1809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases), we found no increased breast cancer risk for either CL/P cases (hazard ratio [HR], 1.23; 95% confidence interval (CI), 0.92-1.63), mothers of children with CL/P (HR, 0.93; 95% CI, 0.80-1.08), or sisters of CL/P cases (HR, 0.94; 95% CI, 0.55-1.60), nor was there any significant differences in age of onset. CONCLUSION: Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and CL/P. However, in this population-based study we were not able to confirm a general increase in the risk of breast cancer among female subjects in families with CL/P.
Authors: Ev Stralen; R J Leguit; H Begthel; L Michaux; A Buijs; H Lemmens; J M Scheiff; C Doyen; P Pierre; F Forget; H C Clevers; Bjeg Bast Journal: Leukemia Date: 2008-10-02 Impact factor: 11.528
Authors: K Osoegawa; G M Vessere; K H Utami; M A Mansilla; M K Johnson; B M Riley; J L'Heureux; R Pfundt; J Staaf; W A van der Vliet; A C Lidral; E F P M Schoenmakers; A Borg; B C Schutte; E J Lammer; J C Murray; P J de Jong Journal: J Med Genet Date: 2007-09-14 Impact factor: 6.318
Authors: Renato Menezes; Mary Louise Marazita; Toby Goldstein McHenry; Margaret E Cooper; Kathleen Bardi; Carla Brandon; Ariadne Letra; Rick A Martin; Alexandre Rezende Vieira Journal: J Am Dent Assoc Date: 2009-01 Impact factor: 3.634
Authors: Timothy R Rebbeck; Angela DeMichele; Teo V Tran; Saarene Panossian; Greta R Bunin; Andrea B Troxel; Brian L Strom Journal: Carcinogenesis Date: 2008-11-20 Impact factor: 4.944
Authors: Fedik Rahimov; Mary L Marazita; Axel Visel; Margaret E Cooper; Michael J Hitchler; Michele Rubini; Frederick E Domann; Manika Govil; Kaare Christensen; Camille Bille; Mads Melbye; Astanand Jugessur; Rolv T Lie; Allen J Wilcox; David R Fitzpatrick; Eric D Green; Peter A Mossey; Julian Little; Regine P Steegers-Theunissen; Len A Pennacchio; Brian C Schutte; Jeffrey C Murray Journal: Nat Genet Date: 2008-10-05 Impact factor: 38.330
Authors: Nicholas Rodriguez; Lorena Maili; Brett T Chiquet; Susan H Blanton; Jacqueline T Hecht; Ariadne Letra Journal: Birth Defects Res Date: 2018-06-19 Impact factor: 2.344
Authors: George L Wehby; Dorthe Almind Pedersen; Jeffrey C Murray; Kaare Christensen Journal: BMC Health Serv Res Date: 2012-03-09 Impact factor: 2.655
Authors: Zena T Wolf; Harrison A Brand; John R Shaffer; Elizabeth J Leslie; Boaz Arzi; Cali E Willet; Timothy C Cox; Toby McHenry; Nicole Narayan; Eleanor Feingold; Xioajing Wang; Saundra Sliskovic; Nili Karmi; Noa Safra; Carla Sanchez; Frederic W B Deleyiannis; Jeffrey C Murray; Claire M Wade; Mary L Marazita; Danika L Bannasch Journal: PLoS Genet Date: 2015-03-23 Impact factor: 5.917
Authors: Sarah W Curtis; Daniel Chang; Miranda R Sun; Michael P Epstein; Jeffrey C Murray; Eleanor Feingold; Terri H Beaty; Seth M Weinberg; Mary L Marazita; Robert J Lipinski; Jenna C Carlson; Elizabeth J Leslie Journal: Genet Epidemiol Date: 2021-06-15 Impact factor: 2.135