OBJECTIVE: To explore the relationship between intraoperative regional cerebral oxygen saturation (rSO(2)) measured by near-infrared spectroscopy (NIRS) and neurodevelopmental outcome in children after cardiac surgery. METHODS: Cross-sectional neurodevelopmental evaluation at 2 years of age was performed in a cohort of young infants who had surgery for congenital heart disease in 2007. The third edition of Bayley Scales of Infant and Toddler Development (Bayley-III) was used to assess cognitive, language, and motor functioning. Clinical and perioperative data were collected, including intraoperative rSO(2) nadir, rSO(2) percent decrease from baseline, and cumulative minutes of at least 20%, 30%, and 40% decrease from baseline. RESULTS: Twenty-seven patients without chromosomal abnormality were included in analyses. Mean Bayley-III scores fell within 1 standard deviation of the normative mean. Stepwise regression analyses of patient- and procedure-related variables, including rSO(2), demonstrated that cognitive ability was predicted by length of hospital stay and premature birth (58.1% of variance), receptive communication was predicted by length of hospital stay and rSO(2) nadir (40.2% of variance), expressive communication was predicted by birth weight (26.2% of variance), fine motor functioning was predicted by duration of cardiac intensive care unit stay (41.4% of variance), and gross motor functioning was predicted by the presence of a significant comorbidity (43.5% of variance). CONCLUSIONS: In a contemporary cohort of infants undergoing surgery for congenital heart disease, neurodevelopmental outcomes at 2 years of age are largely influenced by patient-related characteristics. Although receptive communication appears to be influenced by rSO(2) nadir, the predictive value of NIRS remains unclear.
OBJECTIVE: To explore the relationship between intraoperative regional cerebral oxygen saturation (rSO(2)) measured by near-infrared spectroscopy (NIRS) and neurodevelopmental outcome in children after cardiac surgery. METHODS: Cross-sectional neurodevelopmental evaluation at 2 years of age was performed in a cohort of young infants who had surgery for congenital heart disease in 2007. The third edition of Bayley Scales of Infant and Toddler Development (Bayley-III) was used to assess cognitive, language, and motor functioning. Clinical and perioperative data were collected, including intraoperative rSO(2) nadir, rSO(2) percent decrease from baseline, and cumulative minutes of at least 20%, 30%, and 40% decrease from baseline. RESULTS: Twenty-seven patients without chromosomal abnormality were included in analyses. Mean Bayley-III scores fell within 1 standard deviation of the normative mean. Stepwise regression analyses of patient- and procedure-related variables, including rSO(2), demonstrated that cognitive ability was predicted by length of hospital stay and premature birth (58.1% of variance), receptive communication was predicted by length of hospital stay and rSO(2) nadir (40.2% of variance), expressive communication was predicted by birth weight (26.2% of variance), fine motor functioning was predicted by duration of cardiac intensive care unit stay (41.4% of variance), and gross motor functioning was predicted by the presence of a significant comorbidity (43.5% of variance). CONCLUSIONS: In a contemporary cohort of infants undergoing surgery for congenital heart disease, neurodevelopmental outcomes at 2 years of age are largely influenced by patient-related characteristics. Although receptive communication appears to be influenced by rSO(2) nadir, the predictive value of NIRS remains unclear.
Authors: Joan Sanchez-de-Toledo; Constantinos Chrysostomou; Ricardo Munoz; Steve Lichtenstein; Cesar A Sao-Avilés; Peter D Wearden; Victor O Morell; Robert S B Clark; Nicole Toney; Michael J Bell Journal: Neurocrit Care Date: 2014-08 Impact factor: 3.210
Authors: Nhu N Tran; Jay Desai; Jodie K Votava-Smith; Mary-Lynn Brecht; Douglas L Vanderbilt; Ashok Panigrahy; Liza Mackintosh; Kenneth M Brady; Bradley S Peterson Journal: J Child Neurol Date: 2022-08-02 Impact factor: 2.363
Authors: Suelen Rosa de Oliveira; Ana Carolina Cabral de Paula Machado; Débora Marques de Miranda; Flávio Dos Santos Campos; Cristina Oliveira Ribeiro; Lívia de Castro Magalhães; Maria Cândida Ferrarez Bouzada Journal: Rev Paul Pediatr Date: 2015-03-20
Authors: Mirthe J Mebius; Gideon J du Marchie Sarvaas; Diana W Wolthuis; Beatrijs Bartelds; Martin C J Kneyber; Arend F Bos; Elisabeth M W Kooi Journal: BMC Pediatr Date: 2017-03-16 Impact factor: 2.125
Authors: Alexis R Cole; Dorothy A Perry; Ali Raza; Arthur P Nedder; Elizabeth Pollack; William L Regan; Sarah J van den Bosch; Brian D Polizzotti; Edward Yang; Daniel Davila; Onur Afacan; Simon K Warfield; Yangming Ou; Brenda Sefton; Allen D Everett; Jeffrey J Neil; Hart G W Lidov; John E Mayer; John N Kheir Journal: JACC Basic Transl Sci Date: 2019-03-27
Authors: Mirthe J Mebius; Catherina M Bilardo; Martin C J Kneyber; Marco Modestini; Tjark Ebels; Rolf M F Berger; Arend F Bos; Elisabeth M W Kooi Journal: PLoS One Date: 2020-03-25 Impact factor: 3.240
Authors: Daniël Bossen; Rosa M de Boer; Hendrika Knoester; Jolanda M Maaskant; Marike van der Schaaf; Mattijs W Alsem; Reinoud J B J Gemke; Job B M van Woensel; Jaap Oosterlaan; Raoul H H Engelbert Journal: Crit Care Explor Date: 2021-06-15