Literature DB >> 22035784

L-DOPA ropes in tRNA(Phe).

Eric A First1.   

Abstract

L-DOPA is the most commonly prescribed drug for the treatment of Parkinson's disease. Here, Moor et al. (2011) report that phenylalanyl-tRNA synthetase catalyzes the misacylation of tRNA(Phe) by L-DOPA, suggesting that it may contribute to the elevated levels of L-DOPA-containing proteins found in patients treated with this drug.
Copyright © 2011 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2011        PMID： 22035784     DOI： 10.1016/j.chembiol.2011.10.008

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  3 in total

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  3 in total

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