OBJECTIVE: Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism. METHODS: Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters. RESULTS: In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP. CONCLUSION: Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.
OBJECTIVE: Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism. METHODS: Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters. RESULTS: In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP. CONCLUSION:Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.
Authors: Anke C Fender; Sonja Kleeschulte; Svenja Stolte; Katja Leineweber; Markus Kamler; Johannes Bode; Na Li; Dobromir Dobrev Journal: Basic Res Cardiol Date: 2020-01-07 Impact factor: 17.165
Authors: Godfrey S Temba; Nadira Vadaq; Jun Wan; Vesla Kullaya; Dana Huskens; Tal Pecht; Martin Jaeger; Collins K Boahen; Vasiliki Matzaraki; Wieteke Broeders; Leo A B Joosten; Sultana M H Faradz; Gibson Kibiki; Saskia Middeldorp; Duccio Cavalieri; Paolo Lionetti; Philip G de Groot; Joachim L Schultze; Mihai G Netea; Vinod Kumar; Bas de Laat; Blandina T Mmbaga; Andre J van der Ven; Mark Roest; Quirijn de Mast Journal: J Thromb Haemost Date: 2022-02-10 Impact factor: 16.036