Literature DB >> 2203302

Inhibition of Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.

S Merali1, Y Zhang, D Sloan, S Meshnick.   

Abstract

A new reversed-phase high-pressure liquid chromatography assay procedure for dihydropteroate synthetase (DHPS) that involves the elution of the enzyme incubation solution with a series of three solvents of decreasing polarity (ammonium phosphate buffer, 10% methanol, and 50% methanol) was designed. By this procedure DHPS was detected in Escherichia coli and Pneumocystis carinii with specific activities of 450 and 14 U/mg, respectively. A comparison of the effects of five sulfa drugs on P. carinii DHPS activity revealed that dapsone is the most potent of these drugs.

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Year:  1990        PMID： 2203302      PMCID： PMC171761          DOI： 10.1128/AAC.34.6.1075

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  THE ENZYMATIC SYNTHESIS OF FOLATE-LIKE COMPOUNDS FROM HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHATE.

Authors:  T SHIOTA; M N DISRAELY; M P MCCANN
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS).

Authors:  C J Allegra; B A Chabner; C U Tuazon; D Ogata-Arakaki; B Baird; J C Drake; H Masur
Journal:  Semin Oncol       Date:  1988-04       Impact factor: 4.929

4.  Micro procedure for determination of pyrophosphate and orthophosphate.

Authors:  G B Grindey; C A Nichol
Journal:  Anal Biochem       Date:  1970-01       Impact factor: 3.365

5.  Radioassay for dihydropteroate-synthesizing enzyme activity.

Authors:  K Iwai; O Okinaka
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  Comparison of dosages, intervals, and drugs in the prevention of Pneumocystis carinii pneumonia.

Authors:  W T Hughes
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

7.  Dapsone treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.

Authors:  J Mills; G Leoung; I Medina; P C Hopewell; W T Hughes; C Wofsy
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

8.  Advantages of a modified toluidine blue O stain and bronchoalveolar lavage for the diagnosis of Pneumocystis carinii pneumonia.

Authors:  L L Gosey; R M Howard; F G Witebsky; F P Ognibene; T C Wu; V J Gill; J D MacLowry
Journal:  J Clin Microbiol       Date:  1985-11       Impact factor: 5.948

9.  Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.

Authors:  W T Hughes; P C McNabb; T D Makres; S Feldman
Journal:  Antimicrob Agents Chemother       Date:  1974-03       Impact factor: 5.191

10.  Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides.

Authors:  J L McCullough; T H Maren
Journal:  Antimicrob Agents Chemother       Date:  1973-06       Impact factor: 5.191
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  7 in total

1.  6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Authors:  H C Jackson; K Biggadike; E McKilligin; O S Kinsman; S F Queener; A Lane; J E Smith
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

2.  Catalysis and sulfa drug resistance in dihydropteroate synthase.

Authors:  Mi-Kyung Yun; Yinan Wu; Zhenmei Li; Ying Zhao; M Brett Waddell; Antonio M Ferreira; Richard E Lee; Donald Bashford; Stephen W White
Journal:  Science       Date:  2012-03-02       Impact factor: 47.728

3.  The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Authors:  Mi-Kyung Yun; Daniel Hoagland; Gyanendra Kumar; M Brett Waddell; Charles O Rock; Richard E Lee; Stephen W White
Journal:  Bioorg Med Chem       Date:  2014-02-25       Impact factor: 3.641

4.  Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs.

Authors:  Y Zhang; S R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

5.  Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.

Authors:  L C Chio; L A Bolyard; M Nasr; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Acquisition and synthesis of folates by obligate intracellular bacteria of the genus Chlamydia.

Authors:  H Fan; R C Brunham; G McClarty
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

7.  Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.

Authors:  Y L Hong; P A Hossler; D H Calhoun; S R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  7 in total

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