Literature DB >> 22018778

TGF-beta signalling in colon carcinogenesis.

Pavlos Lampropoulos1, Adamantia Zizi-Sermpetzoglou, Spyros Rizos, Alkiviadis Kostakis, Nikolaos Nikiteas, Athanasios G Papavassiliou.   

Abstract

Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway. The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-β signalling cascade in colorectal carcinogenesis and provide some new molecular insights that may aid efforts towards targeted antitumor therapies.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 22018778     DOI： 10.1016/j.canlet.2011.09.041

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  65 in total

1.  Transforming Growth Factor Beta 2 Inhibits Growth and Proliferation Potential of Smad4 and p53 Mutated Human Colon Adenocarcinoma Cells.

Authors:  Ramamoorthi Ganesan; Nageswaran Sivalingam
Journal:  Pathol Oncol Res       Date:  2018-06-08       Impact factor: 3.201

Review 2.  Targeting TGF-β signaling in cancer.

Authors:  Lior H Katz; Ying Li; Jiun-Sheng Chen; Nina M Muñoz; Avijit Majumdar; Jian Chen; Lopa Mishra
Journal:  Expert Opin Ther Targets       Date:  2013-05-07       Impact factor: 6.902

3.  Shared and independent colorectal cancer risk alleles in TGFβ-related genes in African and European Americans.

Authors:  Sonia S Kupfer; Andrew D Skol; Ellie Hong; Anton Ludvik; Rick A Kittles; Temitope O Keku; Robert S Sandler; Nathan A Ellis
Journal:  Carcinogenesis       Date:  2014-04-21       Impact factor: 4.944

4.  Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.

Authors:  Elzbieta A Swietlicki; Shashi Bala; Jianyun Lu; Anisa Shaker; Gowri Kularatna; Marc S Levin; Deborah C Rubin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-07-25       Impact factor: 4.052

Review 5.  Cancer cells remodel themselves and vasculature to overcome the endothelial barrier.

Authors:  Anitha K Shenoy; Jianrong Lu
Journal:  Cancer Lett       Date:  2014-10-31       Impact factor: 8.679

Review 6.  Animal models of colorectal cancer.

Authors:  Robert L Johnson; James C Fleet
Journal:  Cancer Metastasis Rev       Date:  2013-06       Impact factor: 9.264

7.  MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer.

Authors:  Kandy T Velázquez; Reilly T Enos; Jamie L McClellan; Taryn L Cranford; Ioulia Chatzistamou; Udai P Singh; Mitzi Nagarkatti; Prakash S Nagarkatti; Daping Fan; E Angela Murphy
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2016-01-07       Impact factor: 4.052

8.  Impact of fecal microbiota transplantation on TGF-β1/Smads/ERK signaling pathway of endotoxic acute lung injury in rats.

Authors:  Bo Li; Guo-Fang Yin; Yu-Lei Wang; Yi-Ming Tan; Cheng-Liang Huang; Xian-Ming Fan
Journal:  3 Biotech       Date:  2020-01-20       Impact factor: 2.406

9.  APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-β1/ERK signaling pathway in human colorectal cancer cells.

Authors:  Feng Wang; Lin Chen; Hongbin Ni; Guihua Wang; Weifeng Ding; Hui Cong; Shaoqing Ju; Shumei Yang; Huimin Wang
Journal:  Mol Cell Biochem       Date:  2013-07-20       Impact factor: 3.396

10.  OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer.

Authors:  Yang Li; Lei Li; Jun Qin; Junyi Wu; Xueming Dai; Junming Xu
Journal:  Oncogene       Date:  2020-10-13       Impact factor: 9.867
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