| Literature DB >> 22017238 |
Carl Wibom1, Sara Sjöström, Roger Henriksson, Thomas Brännström, Helle Broholm, Patrik Rydén, Christoffer Johansen, Helle Collatz-Laier, Sara Hepworth, Patricia A McKinney, Lara Bethke, Richard S Houlston, Ulrika Andersson, Beatrice S Melin.
Abstract
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.Entities:
Mesh：
Substances：
Year: 2011 PMID： 22017238 DOI： 10.3109/0284186X.2011.616284
Source DB: PubMed Journal: Acta Oncol ISSN： 0284-186X Impact factor: 4.089