Literature DB >> 22014567

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

Lisa Kinch1, Nick V Grishin, James Brugarolas.   

Abstract

Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22014567      PMCID： PMC3226726          DOI： 10.1016/j.ccr.2011.10.005

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.

Authors:  Chiara Bardella; Mona El-Bahrawy; Norma Frizzell; Julie Adam; Nicola Ternette; Emine Hatipoglu; Kimberley Howarth; Linda O'Flaherty; Ian Roberts; Gareth Turner; Jennifer Taylor; Konstantinos Giaslakiotis; Valentine M Macaulay; Adrian L Harris; Ashish Chandra; Heli J Lehtonen; Virpi Launonen; Lauri A Aaltonen; Christopher W Pugh; Radu Mihai; David Trudgian; Benedikt Kessler; John W Baynes; Peter J Ratcliffe; Ian P Tomlinson; Patrick J Pollard
Journal:  J Pathol       Date:  2011-06-01       Impact factor: 7.996

Review 2.  Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.

Authors:  John D Hayes; Michael McMahon; Sudhir Chowdhry; Albena T Dinkova-Kostova
Journal:  Antioxid Redox Signal       Date:  2010-08-14       Impact factor: 8.401

3.  An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.

Authors:  Aikseng Ooi; Jing-Chii Wong; David Petillo; Douglas Roossien; Victoria Perrier-Trudova; Douglas Whitten; Bernice Wong Hui Min; Min-Han Tan; Zhongfa Zhang; Ximing J Yang; Ming Zhou; Betty Gardie; Vincent Molinié; Stéphane Richard; Puay Hoon Tan; Bin Tean Teh; Kyle A Furge
Journal:  Cancer Cell       Date:  2011-10-18       Impact factor: 31.743

4.  Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.

Authors:  Toshihiko Ogura; Kit I Tong; Kazuhiro Mio; Yuusuke Maruyama; Hirofumi Kurokawa; Chikara Sato; Masayuki Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-27       Impact factor: 11.205

Review 5.  Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Authors:  Keiko Taguchi; Hozumi Motohashi; Masayuki Yamamoto
Journal:  Genes Cells       Date:  2011-02       Impact factor: 1.891

6.  Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Authors:  Ian P M Tomlinson; N Afrina Alam; Andrew J Rowan; Ella Barclay; Emma E M Jaeger; David Kelsell; Irene Leigh; Patricia Gorman; Hanan Lamlum; Shamima Rahman; Rebecca R Roylance; Simon Olpin; Stephen Bevan; Karen Barker; Nicholas Hearle; Richard S Houlston; Maija Kiuru; Rainer Lehtonen; Auli Karhu; Susa Vilkki; Päivi Laiho; Carita Eklund; Outi Vierimaa; Kristiina Aittomäki; Marja Hietala; Pertti Sistonen; Anders Paetau; Reijo Salovaara; Riitta Herva; Virpi Launonen; Lauri A Aaltonen
Journal:  Nat Genet       Date:  2002-02-25       Impact factor: 38.330

7.  Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Authors:  Christian Frezza; Liang Zheng; Ori Folger; Kartik N Rajagopalan; Elaine D MacKenzie; Livnat Jerby; Massimo Micaroni; Barbara Chaneton; Julie Adam; Ann Hedley; Gabriela Kalna; Ian P M Tomlinson; Patrick J Pollard; Dave G Watson; Ralph J Deberardinis; Tomer Shlomi; Eytan Ruppin; Eyal Gottlieb
Journal:  Nature       Date:  2011-08-17       Impact factor: 49.962

8.  Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.

Authors:  Toshinari Yamasaki; Tram Anh T Tran; Orhan K Oz; Ganesh V Raj; Roderich E Schwarz; Ralph J Deberardinis; Xuewu Zhang; James Brugarolas
Journal:  Nat Rev Urol       Date:  2011-02-08       Impact factor: 14.432

9.  Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

Authors:  Julie Adam; Emine Hatipoglu; Linda O'Flaherty; Nicola Ternette; Natasha Sahgal; Helen Lockstone; Dilair Baban; Emma Nye; Gordon W Stamp; Kathryn Wolhuter; Marcus Stevens; Roman Fischer; Peter Carmeliet; Patrick H Maxwell; Chris W Pugh; Norma Frizzell; Tomoyoshi Soga; Benedikt M Kessler; Mona El-Bahrawy; Peter J Ratcliffe; Patrick J Pollard
Journal:  Cancer Cell       Date:  2011-10-18       Impact factor: 38.585

10.  Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.

Authors:  Min Zhuang; Matthew F Calabrese; Jiang Liu; M Brett Waddell; Amanda Nourse; Michal Hammel; Darcie J Miller; Helen Walden; David M Duda; Steven N Seyedin; Timothy Hoggard; J Wade Harper; Kevin P White; Brenda A Schulman
Journal:  Mol Cell       Date:  2009-10-09       Impact factor: 17.970
  10 in total
  43 in total

1.  Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila.

Authors:  Jyoti R Misra; Geanette Lam; Carl S Thummel
Journal:  Insect Biochem Mol Biol       Date:  2013-10-05       Impact factor: 4.714

Review 2.  NRF2 and cancer: the good, the bad and the importance of context.

Authors:  Michael B Sporn; Karen T Liby
Journal:  Nat Rev Cancer       Date:  2012-07-19       Impact factor: 60.716

3.  Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite.

Authors:  Minervo Perez; Daniel W Bak; Sarah E Bergholtz; Daniel R Crooks; Bhargav Srinivas Arimilli; Youfeng Yang; Eranthie Weerapana; W Marston Linehan; Jordan L Meier
Journal:  J Biol Chem       Date:  2020-08-19       Impact factor: 5.157

4.  Omics Integration for Mitochondria Systems Biology.

Authors:  Xin Hu; Young-Mi Go; Dean P Jones
Journal:  Antioxid Redox Signal       Date:  2020-02-03       Impact factor: 8.401

Review 5.  Oncometabolites in renal cancer.

Authors:  Cissy Yong; Grant D Stewart; Christian Frezza
Journal:  Nat Rev Nephrol       Date:  2019-10-21       Impact factor: 28.314

Review 6.  Renal cell carcinoma: molecular biology and targeted therapy.

Authors:  Daniel Su; Lambros Stamatakis; Eric A Singer; Ramaprasad Srinivasan
Journal:  Curr Opin Oncol       Date:  2014-05       Impact factor: 3.645

7.  Integrated molecular analysis of clear-cell renal cell carcinoma.

Authors:  Yusuke Sato; Tetsuichi Yoshizato; Yuichi Shiraishi; Shigekatsu Maekawa; Yusuke Okuno; Takumi Kamura; Teppei Shimamura; Aiko Sato-Otsubo; Genta Nagae; Hiromichi Suzuki; Yasunobu Nagata; Kenichi Yoshida; Ayana Kon; Yutaka Suzuki; Kenichi Chiba; Hiroko Tanaka; Atsushi Niida; Akihiro Fujimoto; Tatsuhiko Tsunoda; Teppei Morikawa; Daichi Maeda; Haruki Kume; Sumio Sugano; Masashi Fukayama; Hiroyuki Aburatani; Masashi Sanada; Satoru Miyano; Yukio Homma; Seishi Ogawa
Journal:  Nat Genet       Date:  2013-06-24       Impact factor: 38.330

8.  Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.

Authors:  Imke Stachel; Claudia Geismann; Konrad Aden; Florian Deisinger; Philip Rosenstiel; Stefan Schreiber; Susanne Sebens; Alexander Arlt; Heiner Schäfer
Journal:  J Biol Chem       Date:  2013-12-05       Impact factor: 5.157

9.  Photoinducible Oncometabolite Detection.

Authors:  Rhushikesh A Kulkarni; Chloe A Briney; Daniel R Crooks; Sarah E Bergholtz; Chandrasekhar Mushti; Stephen J Lockett; Andrew N Lane; Teresa W-M Fan; Rolf E Swenson; W Marston Linehan; Jordan L Meier
Journal:  Chembiochem       Date:  2018-12-13       Impact factor: 3.164

Review 10.  Functions of autophagy in normal and diseased liver.

Authors:  Mark J Czaja; Wen-Xing Ding; Terrence M Donohue; Scott L Friedman; Jae-Sung Kim; Masaaki Komatsu; John J Lemasters; Antoinette Lemoine; Jiandie D Lin; Jing-hsiung James Ou; David H Perlmutter; Glenn Randall; Ratna B Ray; Allan Tsung; Xiao-Ming Yin
Journal:  Autophagy       Date:  2013-05-22       Impact factor: 16.016
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