| Literature DB >> 22003129 |
Laura M Heiser1, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C Benz, Theodore C Goldstein, Sam Ng, William J Gibb, Nicholas J Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W Wood, Peter G Smith, Lyubomir T Vassilev, Bryan T Hennessy, Joel Greshock, Kurtis E Bachman, Mary Ann Hardwicke, John W Park, Laurence J Marton, Denise M Wolf, Eric A Collisson, Richard M Neve, Gordon B Mills, Terence P Speed, Heidi S Feiler, Richard F Wooster, David Haussler, Joshua M Stuart, Joe W Gray, Paul T Spellman.
Abstract
Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.Entities:
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Year: 2011 PMID： 22003129 PMCID： PMC3286973 DOI： 10.1073/pnas.1018854108
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205