BACKGROUND: The aim of this multi-center phase II study was to clarify the clinical benefit of an opioid-based pain control program for head and neck cancer patients during chemoradiotherapy. PATIENTS AND METHODS: Head and neck cancer patients who were to receive definitive or postoperative chemoradiotherapy were enrolled. The opioid-based pain control program consisted of a three-step ladder, with basic regimens of: The primary endpoint of this study was compliance with radiotherapy. RESULTS: A total of 101 patients from 10 institutions were registered between February 2008 and May 2009 and included in the analysis. The major combination chemotherapy regimen was cisplatin alone (76%). The rate of completion of radiotherapy was 99% and the rate of unplanned breaks in radiotherapy was 13% (13/101, 90% confidence interval: 9.9-16.5%). Median maximum quantity of morphine used per day was 35 mg (range 0-150 mg). CONCLUSIONS: Use of a systematic pain control program may improve compliance with CRT.
BACKGROUND: The aim of this multi-center phase II study was to clarify the clinical benefit of an opioid-based pain control program for head and neck cancerpatients during chemoradiotherapy. PATIENTS AND METHODS: Head and neck cancerpatients who were to receive definitive or postoperative chemoradiotherapy were enrolled. The opioid-based pain control program consisted of a three-step ladder, with basic regimens of: The primary endpoint of this study was compliance with radiotherapy. RESULTS: A total of 101 patients from 10 institutions were registered between February 2008 and May 2009 and included in the analysis. The major combination chemotherapy regimen was cisplatin alone (76%). The rate of completion of radiotherapy was 99% and the rate of unplanned breaks in radiotherapy was 13% (13/101, 90% confidence interval: 9.9-16.5%). Median maximum quantity of morphine used per day was 35 mg (range 0-150 mg). CONCLUSIONS: Use of a systematic pain control program may improve compliance with CRT.
Authors: Jessica D McDermott; Megan Eguchi; William A Stokes; Arya Amini; Mohammad Hararah; Ding Ding; Allison Valentine; Cathy J Bradley; Sana D Karam Journal: Otolaryngol Head Neck Surg Date: 2018-11-06 Impact factor: 3.497
Authors: John Pang; Kathryn R Tringale; Viridiana J Tapia; William J Moss; Megan E May; Timothy Furnish; Linda Barnachea; Kevin T Brumund; Assuntina G Sacco; Robert A Weisman; Quyen T Nguyen; Jeffrey P Harris; Charles S Coffey; Joseph A Califano Journal: JAMA Otolaryngol Head Neck Surg Date: 2017-12-01 Impact factor: 6.223