| Literature DB >> 21999103 |
Taichi Kano1, Hisashi Sugimoto, Keiji Maruoka.
Abstract
A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and α-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst.Entities:
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Year: 2011 PMID： 21999103 DOI： 10.1021/ja208873k
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419