Literature DB >> 21997444

Modifications on the carboxylic function of kynurenic acid.

Ferenc Fülöp1, István Szatmári, József Toldi, László Vécsei.   

Abstract

Pharmacological and histological studies of ten new amides of kynurenic acid revealed that N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride has effective neuroprotective properties. Namely, this molecule is: (1) proved to be an effective inhibitor of excitatory synaptic transmission in the CA1 region of the hippocampus both in in vitro and ex vivo studies, (2) in four vessel occlusion model of transient global forebrain ischaemia, measuring the rate of hippocampal CA1 pyramidal cell loss and preservation of long-term potentiation at Schaffer collateral-CA1 synapses, the neuroprotective potential was represented. N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride administration significantly diminished hippocampal CA1 cell loss and preserved LTP expression.

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Year:  2011        PMID： 21997444     DOI： 10.1007/s00702-011-0721-7

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  20 in total

Review 1.  Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.

Authors:  H Németh; J Toldi; L Vécsei
Journal:  J Neural Transm Suppl       Date:  2006

2.  Kynurenic acid has a dual action on AMPA receptor responses.

Authors:  Christina Prescott; Autumn M Weeks; Kevin J Staley; Kathryn M Partin
Journal:  Neurosci Lett       Date:  2006-04-27       Impact factor: 3.046

3.  The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.

Authors:  C Hilmas; E F Pereira; M Alkondon; A Rassoulpour; R Schwarcz; E X Albuquerque
Journal:  J Neurosci       Date:  2001-10-01       Impact factor: 6.167

4.  Distribution, synthesis, and absorption of kynurenic acid in plants.

Authors:  Michal P Turski; Monika Turska; Wojciech Zgrajka; Magdalena Bartnik; Tomasz Kocki; Waldemar A Turski
Journal:  Planta Med       Date:  2010-12-14       Impact factor: 3.352

Review 5.  Kynurenic acid antagonists and kynurenine pathway inhibitors.

Authors:  T W Stone
Journal:  Expert Opin Investig Drugs       Date:  2001-04       Impact factor: 6.206

6.  Endogenous level of kynurenic acid and activities of kynurenine aminotransferases following transient global ischemia in the gerbil hippocampus.

Authors:  Elzbieta Luchowska; Piotr Luchowski; Anna Sarnowska; Marian Wielosz; Waldemar A Turski; Ewa M Urbańska
Journal:  Pol J Pharmacol       Date:  2003 May-Jun

Review 7.  Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives.

Authors:  F Fülöp; I Szatmári; E Vámos; D Zádori; J Toldi; L Vécsei
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

8.  Presence of kynurenic acid in food and honeybee products.

Authors:  Michal P Turski; Monika Turska; Wojciech Zgrajka; Damian Kuc; Waldemar A Turski
Journal:  Amino Acids       Date:  2008-01-30       Impact factor: 3.520

9.  Electrochemical and in vitro evaluation of the redox-properties of kynurenine species.

Authors:  Gregory I Giles; Catriona A Collins; Trevor W Stone; C Jacob
Journal:  Biochem Biophys Res Commun       Date:  2003-01-17       Impact factor: 3.575

10.  [Preparation and definition of Ginkgo biloba extract].

Authors:  K Drieu
Journal:  Presse Med       Date:  1986-09-25       Impact factor: 1.228
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  10 in total

1.  Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72).

Authors:  M Lukács; K Warfvinge; J Tajti; F Fülöp; J Toldi; L Vécsei; L Edvinsson
Journal:  J Headache Pain       Date:  2017-03-23       Impact factor: 7.277

2.  Pre-treatment with new kynurenic acid amide dose-dependently prevents the nitroglycerine-induced neuronal activation and sensitization in cervical part of trigemino-cervical complex.

Authors:  Annamária Fejes-Szabó; Zsuzsanna Bohár; Enikő Vámos; Gábor Nagy-Grócz; Lilla Tar; Gábor Veres; Dénes Zádori; Márton Szentirmai; János Tajti; István Szatmári; Ferenc Fülöp; József Toldi; Árpád Párdutz; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2014-01-03       Impact factor: 3.575

3.  Kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells.

Authors:  Eszter Lajkó; Bernadett Tuka; Ferenc Fülöp; István Krizbai; József Toldi; Kálmán Magyar; László Vécsei; László Kőhidai
Journal:  J Neural Transm (Vienna)       Date:  2018-01-13       Impact factor: 3.575

Review 4.  Changing the face of kynurenines and neurotoxicity: therapeutic considerations.

Authors:  Zsuzsanna Bohár; József Toldi; Ferenc Fülöp; László Vécsei
Journal:  Int J Mol Sci       Date:  2015-04-29       Impact factor: 5.923

5.  Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.

Authors:  A Csáti; L Edvinsson; L Vécsei; J Toldi; F Fülöp; J Tajti; K Warfvinge
Journal:  J Headache Pain       Date:  2015-12-01       Impact factor: 7.277

6.  The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression.

Authors:  Yvette Mándi; Valéria Endrész; Timea Mosolygó; Katalin Burián; Ildikó Lantos; Ferenc Fülöp; István Szatmári; Bálint Lőrinczi; Attila Balog; László Vécsei
Journal:  Front Immunol       Date:  2019-06-21       Impact factor: 7.561

7.  Divergent Effects of the N-Methyl-D-Aspartate Receptor Antagonist Kynurenic Acid and the Synthetic Analog SZR-72 on Microcirculatory and Mitochondrial Dysfunction in Experimental Sepsis.

Authors:  László Juhász; Attila Rutai; Roland Fejes; Szabolcs P Tallósy; Marietta Z Poles; Andrea Szabó; István Szatmári; Ferenc Fülöp; László Vécsei; Mihály Boros; József Kaszaki
Journal:  Front Med (Lausanne)       Date:  2020-11-27

8.  Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains.

Authors:  Melinda Szabo; Noémi Lajkó; Karolina Dulka; István Szatmári; Ferenc Fülöp; András Mihály; László Vécsei; Karoly Gulya
Journal:  Int J Mol Sci       Date:  2022-01-19       Impact factor: 5.923

9.  KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion.

Authors:  M Lukács; K Warfvinge; L S Kruse; J Tajti; F Fülöp; J Toldi; L Vécsei; L Edvinsson
Journal:  J Headache Pain       Date:  2016-07-05       Impact factor: 7.277

10.  Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs.

Authors:  Evelin Fehér; István Szatmári; Tamás Dudás; Anna Zalatnai; Tamás Farkas; Bálint Lőrinczi; Ferenc Fülöp; László Vécsei; József Toldi
Journal:  Molecules       Date:  2019-09-26       Impact factor: 4.411
  10 in total

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