Literature DB >> 19929784

Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives.

F Fülöp1, I Szatmári, E Vámos, D Zádori, J Toldi, L Vécsei.   

Abstract

The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.

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Year:  2009        PMID： 19929784     DOI： 10.2174/092986709789909602

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  25 in total

1.  Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

Authors:  Dénes Zádori; Gábor Nyiri; András Szonyi; István Szatmári; Ferenc Fülöp; József Toldi; Tamás F Freund; László Vécsei; Péter Klivényi
Journal:  J Neural Transm (Vienna)       Date:  2010-12-31       Impact factor: 3.575

2.  Behavioural studies with a newly developed neuroprotective KYNA-amide.

Authors:  Levente Gellért; Dániel Varga; Marian Ruszka; József Toldi; Tamás Farkas; István Szatmári; Ferenc Fülöp; László Vécsei; Zsolt Kis
Journal:  J Neural Transm (Vienna)       Date:  2011-08-05       Impact factor: 3.575

Review 3.  Kynurenines in the CNS: recent advances and new questions.

Authors:  László Vécsei; Levente Szalárdy; Ferenc Fülöp; József Toldi
Journal:  Nat Rev Drug Discov       Date:  2012-12-14       Impact factor: 84.694

4.  Exposure to kynurenic acid during adolescence produces memory deficits in adulthood.

Authors:  Cynthia O Akagbosu; Gretchen C Evans; Danielle Gulick; Raymond F Suckow; David J Bucci
Journal:  Schizophr Bull       Date:  2010-12-20       Impact factor: 9.306

Review 5.  Kynurenines in Parkinson's disease: therapeutic perspectives.

Authors:  Dénes Zádori; Péter Klivényi; József Toldi; Ferenc Fülöp; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2011-08-20       Impact factor: 3.575

6.  A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine.

Authors:  Ildikó Demeter; Károly Nagy; Levente Gellért; László Vécsei; Ferenc Fülöp; József Toldi
Journal:  J Neural Transm (Vienna)       Date:  2012-01-10       Impact factor: 3.575

7.  Modifications on the carboxylic function of kynurenic acid.

Authors:  Ferenc Fülöp; István Szatmári; József Toldi; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2011-10-14       Impact factor: 3.575

8.  A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study.

Authors:  Gábor Veres; Annamária Fejes-Szabó; Dénes Zádori; Gábor Nagy-Grócz; Anna M László; Attila Bajtai; István Mándity; Márton Szentirmai; Zsuzsanna Bohár; Klaudia Laborc; István Szatmári; Ferenc Fülöp; László Vécsei; Árpád Párdutz
Journal:  J Neural Transm (Vienna)       Date:  2016-09-14       Impact factor: 3.575

Review 9.  The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.

Authors:  Marta Amaral; Tiago F Outeiro; Nigel S Scrutton; Flaviano Giorgini
Journal:  J Mol Med (Berl)       Date:  2013-05-01       Impact factor: 4.599

Review 10.  Some molecular mechanisms of dopaminergic and glutamatergic dysfunctioning in Parkinson's disease.

Authors:  Dénes Zádori; Levente Szalárdy; József Toldi; Ferenc Fülöp; Péter Klivényi; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2012-11-30       Impact factor: 3.575
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