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Literature DB >> 21991583

An artificial metalloenzyme for olefin metathesis.

Clemens Mayer¹, Dennis G Gillingham, Thomas R Ward, Donald Hilvert.

Abstract

A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

Entities: Chemical Species

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Year: 2011 PMID： 21991583 DOI： 10.1039/c1cc15005g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

23 in total

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4. Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.

Authors: Vikas Tyagi; Gopeekrishnan Sreenilayam; Priyanka Bajaj; Antonio Tinoco; Rudi Fasan
Journal: Angew Chem Int Ed Engl Date: 2016-09-20 Impact factor: 15.336

5. Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.

Authors: Melanie Bordeaux; Vikas Tyagi; Rudi Fasan
Journal: Angew Chem Int Ed Engl Date: 2014-12-23 Impact factor: 15.336

6. Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains.

Authors: Zhihui Zhong; Hao Yang; Chen Zhang; Jared C Lewis
Journal: Organometallics Date: 2012-10-18 Impact factor: 3.876

An artificial metalloenzyme for olefin metathesis.

1. Designing functional metalloproteins: from structural to catalytic metal sites.

Review 2. Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.

3. Interfacing microbial styrene production with a biocompatible cyclopropanation reaction.

4. Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.

5. Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.

6. Synthesis and Catalytic Activity of Amino Acids and Metallopeptides with Catalytically Active Metallocyclic Side Chains.

7. Myoglobin-Catalyzed Olefination of Aldehydes.

8. Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

9. Metal-conjugated affinity labels: a new concept to create enantioselective artificial metalloenzymes.

10. Profluorescent substrates for the screening of olefin metathesis catalysts.