BACKGROUND: Associations between nasal and bronchial impairment have been repeatedly described in chronic obstructive pulmonary disease (COPD), whereas nasal mucociliary clearance (MCC) in COPD patients is not yet fully understood. We studied nasal MCC parameters in COPD patients and compared them with healthy adults (HA) and with cystic fibrosis (CF) patients with compromised MCC. METHODOLOGY: An observational study of 98 COPD ex-smokers and subjects from control groups evaluated for nasal MCC time (NMCCt) and by digital video microscopy of nasal mucosa recording ciliary beat frequency (CBF) and ciliary beat pattern. RESULTS: The NMCCt was decreased in HA compared to those with COPD and decreased in those with COPD compared to those with CF. CBF in COPD was lower compared to HA. The index of ciliary dyskinesia in COPD patients differed from HA. We detected higher NMCCt and lower nasal CBF in patients with chronic bronchitis phenotype (CB) compared to non-CB patients. CONCLUSIONS: We confirmed the presence of impaired nasal MCC in COPD ex-smokers. These impairments were apparent predominantly in the CB phenotype.
BACKGROUND: Associations between nasal and bronchial impairment have been repeatedly described in chronic obstructive pulmonary disease (COPD), whereas nasal mucociliary clearance (MCC) in COPDpatients is not yet fully understood. We studied nasal MCC parameters in COPDpatients and compared them with healthy adults (HA) and with cystic fibrosis (CF) patients with compromised MCC. METHODOLOGY: An observational study of 98 COPD ex-smokers and subjects from control groups evaluated for nasal MCC time (NMCCt) and by digital video microscopy of nasal mucosa recording ciliary beat frequency (CBF) and ciliary beat pattern. RESULTS: The NMCCt was decreased in HA compared to those with COPD and decreased in those with COPD compared to those with CF. CBF in COPD was lower compared to HA. The index of ciliary dyskinesia in COPDpatients differed from HA. We detected higher NMCCt and lower nasal CBF in patients with chronic bronchitis phenotype (CB) compared to non-CB patients. CONCLUSIONS: We confirmed the presence of impaired nasal MCC in COPD ex-smokers. These impairments were apparent predominantly in the CB phenotype.
Authors: Mark T Dransfield; Andrew M Wilhelm; Brian Flanagan; Clifford Courville; Sherry L Tidwell; S Vamsee Raju; Amit Gaggar; Chad Steele; Li Ping Tang; Bo Liu; Steven M Rowe Journal: Chest Date: 2013-08 Impact factor: 9.410
Authors: Mark J Hoegger; Maged Awadalla; Eman Namati; Omar A Itani; Anthony J Fischer; Alexander J Tucker; Ryan J Adam; Geoffrey McLennan; Eric A Hoffman; David A Stoltz; Michael J Welsh Journal: Proc Natl Acad Sci U S A Date: 2014-01-28 Impact factor: 11.205
Authors: Andras Rab; Steven M Rowe; S Vamsee Raju; Zsuzsa Bebok; Sadis Matalon; James F Collawn Journal: Am J Physiol Lung Cell Mol Physiol Date: 2013-08-09 Impact factor: 5.464
Authors: Moira L Aitken; Ranjani Somayaji; Thomas R Hinds; Maricela Pier; Karla Droguett; Mariana Rios; Shawn J Skerrett; Manuel Villalon Journal: Front Physiol Date: 2021-04-23 Impact factor: 4.566
Authors: Peter A Sloane; Suresh Shastry; Andrew Wilhelm; Clifford Courville; Li Ping Tang; Kyle Backer; Elina Levin; S Vamsee Raju; Yao Li; Marina Mazur; Suzanne Byan-Parker; William Grizzle; Eric J Sorscher; Mark T Dransfield; Steven M Rowe Journal: PLoS One Date: 2012-06-29 Impact factor: 3.240