BACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes. OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported. METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical Inc, Mountain View, California, USA) in the swine (n=2) and canine (n=1) models of arterial thrombo-occlusive disease employing autologous thrombin generated thrombi. The angiographic response and the degree of device-clot incorporation were evaluated. High resolution flat panel three-dimensional CT was performed to further define the in vivo device-thrombus-vessel interaction. Finally, samples of three swine vessels treated with six passes of the device were explanted for histopathological analysis. RESULTS: A total of 16 clots of variable hardness and consistency were implanted in a variety of vascular settings, including the swine internal maxillary, lingual and forelimb arteries as well as the canine external carotid and vertebral arteries. Thrombolysis in Myocardial Infarction (TIMI) 2-3 reperfusion was achieved in all cases immediately after device deployment. All 16 clots were retrieved after one (n=15) or two (n=1) passes with the device. Histopathological analysis demonstrated severe disruption of the intima but no hemorrhage of media or adventitia. CONCLUSION: The experimental data suggest that the Trevo device is highly effective at achieving immediate reperfusion of occluded arteries without causing any clinically significant disruption of vascular integrity.
BACKGROUND: The currently available mechanical devices fail to achieve recanalization in as many as 20-40% of proximal arterial occlusion strokes. OBJECTIVE: The preclinical evaluation of the safety and efficacy of a novel thrombectomy device designed to achieve immediate flow restoration by quickly removing clot is reported. METHODS: Four confirmatory animal studies were performed with the Trevo device (Concentric Medical Inc, Mountain View, California, USA) in the swine (n=2) and canine (n=1) models of arterial thrombo-occlusive disease employing autologous thrombin generated thrombi. The angiographic response and the degree of device-clot incorporation were evaluated. High resolution flat panel three-dimensional CT was performed to further define the in vivo device-thrombus-vessel interaction. Finally, samples of three swine vessels treated with six passes of the device were explanted for histopathological analysis. RESULTS: A total of 16 clots of variable hardness and consistency were implanted in a variety of vascular settings, including the swine internal maxillary, lingual and forelimb arteries as well as the canine external carotid and vertebral arteries. Thrombolysis in Myocardial Infarction (TIMI) 2-3 reperfusion was achieved in all cases immediately after device deployment. All 16 clots were retrieved after one (n=15) or two (n=1) passes with the device. Histopathological analysis demonstrated severe disruption of the intima but no hemorrhage of media or adventitia. CONCLUSION: The experimental data suggest that the Trevo device is highly effective at achieving immediate reperfusion of occluded arteries without causing any clinically significant disruption of vascular integrity.
Authors: P Mordasini; C Brekenfeld; J V Byrne; U Fischer; M Arnold; S Jung; G Schroth; J Gralla Journal: AJNR Am J Neuroradiol Date: 2012-07-26 Impact factor: 3.825
Authors: F Eugène; J-Y Gauvrit; J-C Ferré; J-C Gentric; A Besseghir; T Ronzière; H Raoult Journal: AJNR Am J Neuroradiol Date: 2014-08-14 Impact factor: 3.825
Authors: Andrea M Herrmann; Stephan Meckel; Matthew J Gounis; Leona Kringe; Edith Motschall; Christoph Mülling; Johannes Boltze Journal: J Cereb Blood Flow Metab Date: 2019-02-07 Impact factor: 6.200
Authors: Hesham Masoud; Thanh N Nguyen; Coleman O Martin; William E Holloway; Sudheer Ambekar; Dileep R Yavagal; Diogo C Haussen; Raul Nogueira; Diego J Lozano; Ajit Puri; Ayman Quateen; Daniela Iancu; Michael G Abraham; Michael Chen; Sonal Mehta; Tim Malisch; Franklin Marden; Robin Novakovic; Daniel Roy; Alain Weill; Alexander M Norbash Journal: Interv Neurol Date: 2015-11-20