OBJECTIVES: The concurrent contributions of dynamic, interrelated late-life parameters, such as body mass index (BMI), cognition, and physical functioning on mortality in the elderly are unclear, as is the influence of APOE genotype. We explored these measures in relation to 7-year mortality in long-lived Italian elderly. DESIGN: A representative, age-stratified, population sample. SETTING: The Treviso Longeva (TRELONG) Study, in Treviso, Italy. PARTICIPANTS: Three hundred eleven men and 357 women, aged 70 years and older (mean age 84 ± 8 years). MEASUREMENTS: Seven-year mortality, BMI, Mini-Mental State Examination (MMSE) score, Activities of Daily Living (ADL), APOE genotype, and a variety of clinical and survey data. RESULTS: In separate age- and sex-adjusted analyses, BMI <18.5 kg/m(2), MMSE ≤24, and ADL <6, were associated with greater 7-year mortality among adults aged 70 years and older. In a multivariate model including all factors, MMSE ≤24, and ADL <6 were associated with greater mortality; BMI ≥30 kg/m(2) was protective. There were no interactions between BMI, MMSE, or ADL. When excluding those dying within 3 years of baseline, only an MMSE ≤24 was related to mortality. APOEε4 was not related to mortality. CONCLUSION: Higher MMSE score, higher ADL score, and higher BMI, independent of age, sex, and other factors, are markers for longer life among northern Italian adults aged 70 years or older. Global cognition, BMI, and physical functioning, assessed by short, simple tests are profound indicators of death within less than a decade.
OBJECTIVES: The concurrent contributions of dynamic, interrelated late-life parameters, such as body mass index (BMI), cognition, and physical functioning on mortality in the elderly are unclear, as is the influence of APOE genotype. We explored these measures in relation to 7-year mortality in long-lived Italian elderly. DESIGN: A representative, age-stratified, population sample. SETTING: The Treviso Longeva (TRELONG) Study, in Treviso, Italy. PARTICIPANTS: Three hundred eleven men and 357 women, aged 70 years and older (mean age 84 ± 8 years). MEASUREMENTS: Seven-year mortality, BMI, Mini-Mental State Examination (MMSE) score, Activities of Daily Living (ADL), APOE genotype, and a variety of clinical and survey data. RESULTS: In separate age- and sex-adjusted analyses, BMI <18.5 kg/m(2), MMSE ≤24, and ADL <6, were associated with greater 7-year mortality among adults aged 70 years and older. In a multivariate model including all factors, MMSE ≤24, and ADL <6 were associated with greater mortality; BMI ≥30 kg/m(2) was protective. There were no interactions between BMI, MMSE, or ADL. When excluding those dying within 3 years of baseline, only an MMSE ≤24 was related to mortality. APOEε4 was not related to mortality. CONCLUSION: Higher MMSE score, higher ADL score, and higher BMI, independent of age, sex, and other factors, are markers for longer life among northern Italian adults aged 70 years or older. Global cognition, BMI, and physical functioning, assessed by short, simple tests are profound indicators of death within less than a decade.
Authors: M Gallucci; S Mazzuco; F Ongaro; E Di Giorgi; P Mecocci; M Cesari; D Albani; G L Forloni; E Durante; G B Gajo; A Zanardo; M Siculi; L Caberlotto; C Regini Journal: J Nutr Health Aging Date: 2013-04 Impact factor: 4.075
Authors: Kumar B Rajan; Lisa L Barnes; Robert S Wilson; Elizabeth A McAninch; Jennifer Weuve; Dominique Sighoko; Denis A Evans Journal: J Am Geriatr Soc Date: 2017-09-12 Impact factor: 5.562
Authors: Tingting Wu; Lu Lu; Li Luo; Yingqi Guo; Liying Ying; Qingliu Tao; Huan Zeng; Lingli Han; Zumin Shi; Yong Zhao Journal: Int J Environ Res Public Health Date: 2017-11-09 Impact factor: 3.390
Authors: Deborah R Gustafson; Qiuhu Shi; Susan Holman; Howard Minkoff; Mardge H Cohen; Michael W Plankey; Richard Havlik; Anjali Sharma; Stephen Gange; Monica Gandhi; Joel Milam; Donald R Hoover Journal: BMJ Open Date: 2017-06-30 Impact factor: 2.692
Authors: Sujuan Gao; Yinlong Jin; Frederick W Unverzagt; Yibin Cheng; Liqin Su; Chenkun Wang; Feng Ma; Ann M Hake; Carla Kettler; Chen Chen; Jingyi Liu; Jianchao Bian; Ping Li; Jill R Murrell; Daniel O Clark; Hugh C Hendrie Journal: Arch Public Health Date: 2014-03-26
Authors: Lilian Vivian; Neide Maria Bruscato; Berenice Maria Werle; Waldemar de Carli; Renata Alonso Gadi Soares; Paulo Caleb de Lima Santos Júnior; Emilio Hideyuki Moriguchi Journal: Arq Bras Cardiol Date: 2020-11 Impact factor: 2.000