Literature DB >> 21988721

Race-specific type 1 diabetes risk of HLA-DR7 haplotypes.

J A Noble1, J Johnson, J A Lane, A M Valdes.   

Abstract

The aim of this study was to test the hypothesis that closely related human leukocyte antigen (HLA) haplotypes containing the DRB1*07:01 gene ['DR7' (DRB1*07:01-DQA1*02:01-DQB1*02:01g or DRB1*07:01-DQA1*03:01-DQB1*02:01g) haplotypes] derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ-α molecule present. A combined total of 98 African American T1D patients from the Type 1 Diabetes Genetics Consortium and from Children's Hospital and Research Center Oakland were genotyped for the HLA class II loci DRB1, DQA1, and DQB1. DNA samples extracted from newborn blood spot cards from African Americans born in California (n = 947) were used as a population-based control group. Among African American cases, the European-derived DRB1*07:01-DQA1*02:01-DQB1*02:01g haplotype was protective for T1D risk (odds ratio (OR) = 0.34; 95% confidence interval (CI) 0.14-0.78; P < 0.011), but the African-derived DRB1*07:01-DQA1*03:01-DQB1*02:01g haplotype increased T1D risk (OR = 3.96; 95% CI 1.94-8.08; P < 5.5E-05). The effect of DRB1*07:01-DQB1*02:01g on T1D susceptibility depends on the DQA1 allele. DRB1*07:01-DQA1*02:01-DQB1*02:01g is protective for T1D; however, the presence of DQA1*03:01 on the DRB1*07:01-DQB1*02:01g haplotype not only renders the DR7 haplotype not protective but also creates a haplotype with significant T1D risk. These data underscore the importance of assessing genetic effects within ethnic context.
© 2011 John Wiley & Sons A/S.

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Year:  2011        PMID： 21988721      PMCID： PMC3193161          DOI： 10.1111/j.1399-0039.2011.01772.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  12 in total

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Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

3.  Trans-racial studies implicate HLA-DQ as a component of genetic susceptibility to type 1 (insulin-dependent) diabetes.

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Journal:  Diabetologia       Date:  1988-12       Impact factor: 10.122

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Authors:  N Risch
Journal:  Am J Hum Genet       Date:  1987-01       Impact factor: 11.025

5.  HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

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Journal:  Nature       Date:  1987 Oct 15-21       Impact factor: 49.962

6.  HLA genotyping in the international Type 1 Diabetes Genetics Consortium.

Authors:  Josyf C Mychaleckyj; Janelle A Noble; Priscilla V Moonsamy; Joyce A Carlson; Michael D Varney; Jeff Post; Wolfgang Helmberg; June J Pierce; Persia Bonella; Anna Lisa Fear; Eva Lavant; Anthony Louey; Sean Boyle; Julie A Lane; Paul Sali; Samuel Kim; Rebecca Rappner; Dustin T Williams; Letitia H Perdue; David M Reboussin; Brian D Tait; Beena Akolkar; Joan E Hilner; Michael W Steffes; Henry A Erlich
Journal:  Clin Trials       Date:  2010-07-01       Impact factor: 2.486

7.  Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Authors:  G Thomson; A M Valdes; J A Noble; I Kockum; M N Grote; J Najman; H A Erlich; F Cucca; A Pugliese; A Steenkiste; J S Dorman; S Caillat-Zucman; R Hermann; J Ilonen; A P Lambert; P J Bingley; K M Gillespie; A Lernmark; C B Sanjeevi; K S Rønningen; D E Undlien; E Thorsby; A Petrone; R Buzzetti; B P C Koeleman; B O Roep; G Saruhan-Direskeneli; F A Uyar; H Günoz; C Gorodezky; C Alaez; B O Boehm; W Mlynarski; H Ikegami; M Berrino; M E Fasano; E Dametto; S Israel; C Brautbar; A Santiago-Cortes; T Frazer de Llado; J-X She; T L Bugawan; J I Rotter; L Raffel; A Zeidler; F Leyva-Cobian; B R Hawkins; S H Chan; L Castano; F Pociot; J Nerup
Journal:  Tissue Antigens       Date:  2007-08

8.  HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.

Authors:  Henry Erlich; Ana Maria Valdes; Janelle Noble; Joyce A Carlson; Mike Varney; Pat Concannon; Josyf C Mychaleckyj; John A Todd; Persia Bonella; Anna Lisa Fear; Eva Lavant; Anthony Louey; Priscilla Moonsamy
Journal:  Diabetes       Date:  2008-02-05       Impact factor: 9.461

9.  HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families.

Authors:  Michael D Varney; Ana Maria Valdes; Joyce A Carlson; Janelle A Noble; Brian D Tait; Persia Bonella; Eva Lavant; Anna Lisa Fear; Anthony Louey; Priscilla Moonsamy; Josyf C Mychaleckyj; Henry Erlich
Journal:  Diabetes       Date:  2010-04-27       Impact factor: 9.461

10.  HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.

Authors:  Janelle A Noble; Ana Maria Valdes; Michael D Varney; Joyce A Carlson; Priscilla Moonsamy; Anna Lisa Fear; Julie A Lane; Eva Lavant; Rebecca Rappner; Anthony Louey; Patrick Concannon; Josyf C Mychaleckyj; Henry A Erlich
Journal:  Diabetes       Date:  2010-08-26       Impact factor: 9.461
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  8 in total

1.  Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.

Authors:  Stig Tollefsen; Kinya Hotta; Xi Chen; Bjørg Simonsen; Kunchithapadam Swaminathan; Irimpan I Mathews; Ludvig M Sollid; Chu-Young Kim
Journal:  J Biol Chem       Date:  2012-02-23       Impact factor: 5.157

2.  HLA-associated phenotypes in youth with autoimmune diabetes.

Authors:  Mary Helen Black; Jean M Lawrence; Catherine Pihoker; Lawrence M Dolan; Andrea Anderson; Beatriz Rodriguez; Santica M Marcovina; Elizabeth J Mayer-Davis; Giuseppina Imperatore; Dana Dabelea
Journal:  Pediatr Diabetes       Date:  2012-08-23       Impact factor: 4.866

3.  HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes.

Authors:  Janelle A Noble; Jameel Johnson; Julie A Lane; Ana M Valdes
Journal:  Diabetes       Date:  2013-06-25       Impact factor: 9.461

4.  HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations.

Authors:  Zain Al Yafei; Steven J Mack; Marion Alvares; Bassam R Ali; Bachar Afandi; Salem A Beshyah; Charu Sharma; Wael Osman; Rajaa Mirghani; Amre Nasr; Sareea Al Remithi; Jamal Al Jubeh; Wasim Y Almawi; Juma AlKaabi; Gehad ElGhazali
Journal:  Front Genet       Date:  2022-03-24       Impact factor: 4.599

5.  HLA class II gene associations in African American type 1 diabetes reveal a protective HLA-DRB1*03 haplotype.

Authors:  J M M Howson; M S Roy; L Zeitels; H Stevens; J A Todd
Journal:  Diabet Med       Date:  2013-03-21       Impact factor: 4.359

6.  Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.

Authors:  Carolyn C Richardson; Kerry A McLaughlin; Diana Morgan; Richard G Feltbower; Michael R Christie
Journal:  Diabetologia       Date:  2015-11-13       Impact factor: 10.122

Review 7.  Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.

Authors:  Mohamed Jahromi; Ebaa Al-Ozairi
Journal:  Dis Markers       Date:  2019-11-20       Impact factor: 3.434

8.  Distribution of HLA-DQ risk genotypes for celiac disease in Ethiopian children.

Authors:  Adugna N Gudeta; Anita Ramelius; Taye T Balcha; Alemayehu Girma; Jorma Ilonen; Daniel Agardh
Journal:  HLA       Date:  2020-10-30       Impact factor: 4.513
  8 in total

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