Literature DB >> 21988105

Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0.

Zoë Fisher1, Andrey Y Kovalevsky, Marat Mustyakimov, David N Silverman, Robert McKenna, Paul Langan.   

Abstract

The neutron structure of wild-type human carbonic anhydrase II at pH 7.8 has been determined to 2.0 Å resolution. Detailed analysis and comparison to the previously determined structure at pH 10.0 show important differences in the protonation of key catalytic residues in the active site as well as a rearrangement of the H-bonded water network. For the first time, a completed H-bonded network stretching from the Zn-bound solvent to the proton shuttling residue, His64, has been directly observed.

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Year:  2011        PMID： 21988105      PMCID： PMC3371383          DOI： 10.1021/bi201487b

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  12 in total

1.  Solvent-mediated proton transfer in catalysis by carbonic anhydrase.

Authors:  David N Silverman; Robert McKenna
Journal:  Acc Chem Res       Date:  2007-06-06       Impact factor: 22.384

2.  Ion-protein coordination: the many faces of a proton.

Authors:  Victor L Davidson
Journal:  Nat Chem       Date:  2011-08-23       Impact factor: 24.427

3.  Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.

Authors:  Zoë Fisher; Jose A Hernandez Prada; Chingkuang Tu; David Duda; Craig Yoshioka; Haiqian An; Lakshmanan Govindasamy; David N Silverman; Robert McKenna
Journal:  Biochemistry       Date:  2005-02-01       Impact factor: 3.162

4.  Neutron structure of human carbonic anhydrase II: implications for proton transfer.

Authors:  S Zoë Fisher; Andrey Y Kovalevsky; John F Domsic; Marat Mustyakimov; Robert McKenna; David N Silverman; Paul A Langan
Journal:  Biochemistry       Date:  2010-01-26       Impact factor: 3.162

5.  Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.

Authors:  S Zoë Fisher; Chingkuang Tu; Deepa Bhatt; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; Robert McKenna; David N Silverman
Journal:  Biochemistry       Date:  2007-03-02       Impact factor: 3.162

6.  Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant.

Authors:  C K Tu; D N Silverman; C Forsman; B H Jonsson; S Lindskog
Journal:  Biochemistry       Date:  1989-09-19       Impact factor: 3.162

7.  Entrapment of carbon dioxide in the active site of carbonic anhydrase II.

Authors:  John F Domsic; Balendu Sankara Avvaru; Chae Un Kim; Sol M Gruner; Mavis Agbandje-McKenna; David N Silverman; Robert McKenna
Journal:  J Biol Chem       Date:  2008-09-02       Impact factor: 5.157

8.  Elucidation of the proton transport mechanism in human carbonic anhydrase II.

Authors:  C Mark Maupin; Robert McKenna; David N Silverman; Gregory A Voth
Journal:  J Am Chem Soc       Date:  2009-06-10       Impact factor: 15.419

9.  Carbon dioxide hydration activity of carbonic anhydrase in mixtures of water and deuterium oxide.

Authors:  K S Venkatasubban; D N Silverman
Journal:  Biochemistry       Date:  1980-10-28       Impact factor: 3.162

10.  Generalized X-ray and neutron crystallographic analysis: more accurate and complete structures for biological macromolecules.

Authors:  Paul D Adams; Marat Mustyakimov; Pavel V Afonine; Paul Langan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-05-15
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  19 in total

1.  Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.

Authors:  Ryszard Michalczyk; Clifford J Unkefer; John-Paul Bacik; Tobias E Schrader; Andreas Ostermann; Andrey Y Kovalevsky; Robert McKenna; Suzanne Zoë Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

Review 2.  Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.

Authors:  Bengt-Harald Jonsson; Anders Liljas
Journal:  Biophys J       Date:  2020-08-27       Impact factor: 4.033

3.  Seeing the chemistry in biology with neutron crystallography.

Authors:  Paul Langan; Julian C-H Chen
Journal:  Phys Chem Chem Phys       Date:  2013-07-15       Impact factor: 3.676

4.  Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.

Authors:  S Zoë Fisher; Mayank Aggarwal; Andrey Y Kovalevsky; David N Silverman; Robert McKenna
Journal:  J Am Chem Soc       Date:  2012-09-04       Impact factor: 15.419

5.  Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.

Authors:  Tyrel Bryan; Javier M González; John P Bacik; Nicholas J DeNunzio; Clifford J Unkefer; Tobias E Schrader; Andreas Ostermann; Debra Dunaway-Mariano; Karen N Allen; S Zoë Fisher
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-08-19

6.  Preliminary time-of-flight neutron diffraction studies of Escherichia coli ABC transport receptor phosphate-binding protein at the Protein Crystallography Station.

Authors:  K H Sippel; J Bacik; F A Quiocho; S Z Fisher
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-05-25       Impact factor: 1.056

7.  Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.

Authors:  Christopher D Boone; Sonika Gill; Chingkuang Tu; David N Silverman; Robert McKenna
Journal:  Arch Biochem Biophys       Date:  2013-09-10       Impact factor: 4.013

8.  Direct observation of hydrogen atom dynamics and interactions by ultrahigh resolution neutron protein crystallography.

Authors:  Julian C-H Chen; B Leif Hanson; S Zoë Fisher; Paul Langan; Andrey Y Kovalevsky
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-04       Impact factor: 11.205

9.  Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.

Authors:  Mayank Aggarwal; Bhargav Kondeti; Chingkuang Tu; C Mark Maupin; David N Silverman; Robert McKenna
Journal:  IUCrJ       Date:  2014-02-28       Impact factor: 4.769

10.  Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.

Authors:  Srabani Taraphder; C Mark Maupin; Jessica M J Swanson; Gregory A Voth
Journal:  J Phys Chem B       Date:  2016-04-20       Impact factor: 2.991
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