Literature DB >> 21987766

Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication.

Mathieu Mateo1, Caroline Carbonnelle, Miguel J Martinez, Olivier Reynard, Audrey Page, Valentina A Volchkova, Viktor E Volchkov.   

Abstract

The structural protein VP24 of Ebola virus (EBOV) is a determinant of virulence in rodent models and possesses an interferon antagonist function. In this study, we investigate the role of VP24 in EBOV replication using RNA interference by small interfering RNA to knock down the expression of this protein in virus-infected cells. We reveal that VP24 is required for assembly of viral nucleocapsids and that silencing of VP24 expression prevents the release of EBOV.

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Year:  2011        PMID： 21987766     DOI： 10.1093/infdis/jir311

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  27 in total

1.  Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography.

Authors:  Tanmay A M Bharat; Takeshi Noda; James D Riches; Verena Kraehling; Larissa Kolesnikova; Stephan Becker; Yoshihiro Kawaoka; John A G Briggs
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-27       Impact factor: 11.205

2.  The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway.

Authors:  Megan R Edwards; Britney Johnson; Chad E Mire; Wei Xu; Reed S Shabman; Lauren N Speller; Daisy W Leung; Thomas W Geisbert; Gaya K Amarasinghe; Christopher F Basler
Journal:  Cell Rep       Date:  2014-03-13       Impact factor: 9.423

3.  Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription.

Authors:  Andrey Ivanov; Palaniappan Ramanathan; Christian Parry; Philipp A Ilinykh; Xionghao Lin; Michael Petukhov; Yuri Obukhov; Tatiana Ammosova; Gaya K Amarasinghe; Alexander Bukreyev; Sergei Nekhai
Journal:  Cell Mol Life Sci       Date:  2019-09-28       Impact factor: 9.261

4.  Analysis of the highly diverse gene borders in Ebola virus reveals a distinct mechanism of transcriptional regulation.

Authors:  Kristina Brauburger; Yannik Boehmann; Yoshimi Tsuda; Thomas Hoenen; Judith Olejnik; Michael Schümann; Hideki Ebihara; Elke Mühlberger
Journal:  J Virol       Date:  2014-08-20       Impact factor: 5.103

5.  VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Authors:  Toni M Schwarz; Megan R Edwards; Audrey Diederichs; Joshua B Alinger; Daisy W Leung; Gaya K Amarasinghe; Christopher F Basler
Journal:  J Virol       Date:  2017-01-31       Impact factor: 5.103

6.  The Integrity of the YxxL Motif of Ebola Virus VP24 Is Important for the Transport of Nucleocapsid-Like Structures and for the Regulation of Viral RNA Synthesis.

Authors:  Yuki Takamatsu; Larissa Kolesnikova; Martin Schauflinger; Takeshi Noda; Stephan Becker
Journal:  J Virol       Date:  2020-04-16       Impact factor: 5.103

7.  Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

Authors:  Megan R Edwards; Christopher F Basler
Journal:  J Infect Dis       Date:  2015-04-29       Impact factor: 5.226

8.  A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity.

Authors:  Ari Watt; Felicien Moukambi; Logan Banadyga; Allison Groseth; Julie Callison; Astrid Herwig; Hideki Ebihara; Heinz Feldmann; Thomas Hoenen
Journal:  J Virol       Date:  2014-06-25       Impact factor: 5.103

9.  Therapeutics for postexposure treatment of Ebola virus infection.

Authors:  Marina Jerebtsova; Sergei Nekhai
Journal:  Future Virol       Date:  2015-03       Impact factor: 1.831

Review 10.  Immune barriers of Ebola virus infection.

Authors:  Anita K McElroy; Elke Mühlberger; César Muñoz-Fontela
Journal:  Curr Opin Virol       Date:  2018-02-16       Impact factor: 7.090
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