| Literature DB >> 29452995 |
Anita K McElroy1, Elke Mühlberger2, César Muñoz-Fontela3.
Abstract
Since its initial emergence in 1976 in northern Democratic Republic of Congo (DRC), Ebola virus (EBOV) has been a global health concern due to its virulence in humans, the mystery surrounding the identity of its host reservoir and the unpredictable nature of Ebola virus disease (EVD) outbreaks. Early after the first clinical descriptions of a disease resembling a 'septic-shock-like syndrome', with coagulation abnormalities and multi-system organ failure, researchers began to evaluate the role of the host immune response in EVD pathophysiology. In this review, we summarize how data gathered during the last 40 years in the laboratory as well as in the field have provided insight into EBOV immunity. From molecular mechanisms involved in EBOV recognition in infected cells, to antigen processing and adaptive immune responses, we discuss current knowledge on the main immune barriers of infection as well as outstanding research questions.Entities:
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Year: 2018 PMID： 29452995 PMCID： PMC5886007 DOI： 10.1016/j.coviro.2018.01.010
Source DB: PubMed Journal: Curr Opin Virol ISSN： 1879-6257 Impact factor: 7.090