Literature DB >> 21987482

Synthesis and anti-candida potential of certain novel 1-[(3-Substituted-3-phenyl)propyl]-1H-imidazoles.

Mohamed Nabil Aboul-Enein1, Aida Abd El-Sattar El-Azzouny, Mohamed Ibrahim Attia, Ola Ahmed Saleh, Amany Lotfy Kansoh.   

Abstract

The synthesis and anti-Candida activity of 1-[(3-aroyloxy-3-phenyl)propyl]-1H-imidazoles 5a-f and 1-[(3-alkyl/aralkyl/phenyl-3-phenyl)propan-3-ol]-1H-imidazoles 5g-j are reported. The influence of the ester formation and different substitutions on the anti-Candida activity of the alcohol 4 was investigated. Among the newly developed bioactive chemical entities, compounds 5b and 5c displayed minimum inhibitory concentrations (MICs) against Candida albicans and Candida pseudotropicales comparable to that of tioconazole and more potent than miconazole.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21987482     DOI： 10.1002/ardp.201000224

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  6 in total

1.  Synthesis, X-ray Single Crystal Structure, Molecular Docking and DFT Computations on N-[(1E)-1-(2H-1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]-hydroxylamine: A New Potential Antifungal Agent Precursor.

Authors:  Reem I Al-Wabli; Alwah R Al-Ghamdi; Hazem A Ghabbour; Mohamed H Al-Agamy; James Clemy Monicka; Issac Hubert Joe; Mohamed I Attia
Journal:  Molecules       Date:  2017-02-28       Impact factor: 4.411

2.  3-(1H-Imidazol-1-yl)-1-phenyl-propan-1-ol.

Authors:  Hoong-Kun Fun; Ching Kheng Quah; Mohamed I Attia; Hatem A Abdel-Aziz; Khalid A Al-Rashood
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-10

3.  1-Aryl-3-(1H-imidazol-1-yl)propan-1-ol esters: synthesis, anti-Candida potential and molecular modeling studies.

Authors:  Mohamed I Attia; Awwad A Radwan; Azza S Zakaria; Maha S Almutairi; Soraya W Ghoneim
Journal:  Chem Cent J       Date:  2013-10-25       Impact factor: 4.215

4.  Synthesis, Single Crystal X-ray Analysis, and Antifungal Profiling of Certain New Oximino Ethers Bearing Imidazole Nuclei.

Authors:  Reem I Al-Wabli; Alwah R Al-Ghamdi; Hazem A Ghabbour; Mohamed H Al-Agamy; Mohamed I Attia
Journal:  Molecules       Date:  2017-11-03       Impact factor: 4.411

5.  Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole-imidazole molecular hybrids bearing ester functionalities.

Authors:  Reem I Al-Wabli; Alwah R Al-Ghamdi; Hazem A Ghabbour; Mohamed H Al-Agamy; Mohamed I Attia
Journal:  Drug Des Devel Ther       Date:  2019-02-26       Impact factor: 4.162

6.  Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.

Authors:  Mohamed I Attia; Mohamed N Aboul-Enein; Aida A El-Azzouny; Yousreya A Maklad; Hazem A Ghabbour
Journal:  ScientificWorldJournal       Date:  2014-01-12
  6 in total

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